Lipocalin-2/LCN2 from mouse
SIGMA/SRP6537 - recombinant, expressed in HEK 293 cells, ≥90% (SDS-PAGE)
Synonym: 24p3; MSFI; NGAL; NGAL; Neutrophil Gelatinase-
Product Type: Chemical
| assay | ≥90% (SDS-PAGE) |
| biological source | mouse |
| form | liquid |
| impurities | <0.1 EU/μg endotoxin (LAL test) |
| mol wt | monomer ~250 kDa (Mouse lipocalin-2 aa 1-200 is fused at the C-terminus to a FLAG |
| packaging | pkg of 10 and 50 μg |
| recombinant | expressed in HEK 293 cells |
| shipped in | wet ice |
| storage temp. | −20°C |
| UniProt accession no. | P11672   |
| Biochem/physiol Actions: | LCN2 (lipocalin-2) has also been implicated in a variety of processes including cell differentiation, tumorigenesis, and apoptosis. Polymorphisms in the expression of LCN2 are associated with many cancers such as breast, colorectal, pancreatic, ovarian, gastric, thyroid, ovarian, bladder and kidney cancers. |
| General description: | LCN2 (lipocalin-2), a secreted glycoprotein is an adipokine. It is expressed in various cells like respiratory and intestinal epithelial cells, endothelial cells, renal tubular cells and cardiomyocytes. The gene LCN2 is located on human chromosome 9q34. |
| General description: | Lipocalin-2 (LCN2), also known as oncogene 24p3 or neutrophil gelatinase-associated lipocalin (NGAL), MSFI, The binding of lipocalin-2 to bacterial siderophores is important in the innate immune response to bacterial infection. Upon encountering invading bacteria the toll-like receptors on immune cells stimulate the synthesis and secretion of lipocalin-2. Secreted lipocalin-2 then limits bacterial growth by sequestering iron-containing siderophores. Lipocalin-2 also functions as a growth factor. LCN2 is strongly upregulated during inflammation and is upregulated by interleukin 1 (but not TNF α) in humans. There are indications that some forms of acne could be caused due to the gene not being transcribed, and that Isotretinoin corrects this. NFAT3 (NFATc4) NFAT by blocking the expression of LCN2 inhibits breast carcinoma cell motility. Recent studies have revealed that NGAL plays an important role in the physiopathology of chronic myeloid leukaemia (CML) mediated by BCR-ABL. |
| Physical form: | 0.2 μm-filtered solution in PBS. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥90% (SDS-PAGE) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |