FNDC4
SIGMA/SRP6541 - recombinant, expressed in E. coli, ≥95% (SDS-PAGE)
Synonym: Fibronectin Type III Domain-containing Protein 4; Fibronectin Type III Repeat-containing Protein 1
Product Type: Chemical
| assay | ≥95% (SDS-PAGE) |
| biological source | human |
| form | lyophilized |
| impurities | <0.1 EU/μg endotoxin (LAL test) |
| mol wt | ~160 kDa (Extracellular domain, human aa 45-167 / mouse aa 41-163 is untagged. FNDC4 extracellular domain has 100% identity between human, mouse, rat, dog and monkey.) |
| packaging | pkg of 10 μg |
| recombinant | expressed in E. coli |
| shipped in | wet ice |
| storage temp. | −20°C |
| UniProt accession no. | Q9H6D8   |
| General description: | Irisin is a recently described exercise-induced hormone secreted by skeletal muscle in mice and humans. Irisin activates beige fat cells (beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone Irisin). Irisin is cleaved from the type I membrane protein FNDC5 and improves systemic metabolism by increasing energy expenditure. FNDC4 is an ortholog of FNDC5 with 50% identity and 86% similarity compared to Irisin. FNDC4 as well as FNDC5 are extremely well conserved between species. The function of FNDC4 is unknown. The human FNDC4 gene is highly enriched in liver, brain tissue and adipocytes. |
| Physical form: | Lyophilized in PBS. |
| Reconstitution: | Reconstitute with 100 μL sterile distilled water. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥95% (SDS-PAGE) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |