CIRBP/Cold-inducible RNA-binding protein human
SIGMA/SRP6553 - recombinant, expressed in E. coli, ≥90% (SDS-PAGE)
Synonym: A18HNRNP; CIRP
Product Type: Chemical
Immunoblotting CIRBP Cat. No. SRP6553, SDS PAGE of human recombinant CIRBP.
| assay | ≥90% (SDS-PAGE) |
| biological source | human |
| form | lyophilized |
| impurities | ≤1 EU/μg endotoxin (LAL test) |
| mol wt | 20.5 kDa |
| packaging | pkg of 1 mg |
| pkg of 20 μg | |
| recombinant | expressed in E. coli |
| shipped in | wet ice |
| storage temp. | −70°C |
| UniProt accession no. | Q14011   |
| General description: | CIRBP, also known as cold-inducible RNA-binding protein, plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. CIRBP responds to a wide array of cellular stresses, including short wavelength ultraviolet light (UVC), at the transcriptional and post-translational level. It acts as a translational activator. CIRBP can bind the 3′untranslated region of specific transcripts to stabilize them and facilitate their transport to ribosomes for translation. CIRBP affects NF-κB signaling as opposed to IL1B mRNA stability directly. |
| Physical form: | Lyophilized from sterile 20 mM Tris, 500 mM NaCl, 0.25 M Imidazole, 20% glycerol. |
| Reconstitution: | Detailed reconstitution instructions are sent along with the product |
| Symbol |   GHS07,GHS08 |
| Signal word | Danger |
| Hazard statements | H315 - H319 - H360D |
| Precautionary statements | P201 - P280 - P305 + P351 + P338 - P308 + P313 - P337 + P313 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥90% (SDS-PAGE) |
| Storage Temp. | −70°C |
| UNSPSC | 12352200 |