BRD1 (556-680) GST tag human
SIGMA/SRP6564 - recombinant, expressed in E. coli, ≥95% (SDS-PAGE)
Synonym: BR140-like protein; BRL; BRPF1; BRPF2; Bromodomain and PHD finger-containing protein 2; Bromodomain containing 1; DKFZp686F0325
Product Type: Chemical
assay | ≥95% (SDS-PAGE) |
biological source | human |
form | liquid |
mol wt | 41.1 kDa (556-680 aa + NT GST Tag) |
packaging | pkg of 100 μg |
pkg of 20 μg | |
recombinant | expressed in E. coli |
shipped in | dry ice |
storage temp. | −70°C |
UniProt accession no. | O95696 |
General description: | The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such as those on the N-terminal tails of histones. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as “readers” of histone acetylation marks regulating the transcription of target promoters. BRD1 is a bromodomain containing protein that has been identified as a susceptibility gene in neurological disorders, such as schizophrenia and bipolar affective disorder. This protein can be used for the study of bromodomain binding assays, screening inhibitors, and selectivity profiling. |
Physical form: | 50 mM Tris, pH 7.5, containing 500 mM sodium chloride, 5% glycerol, and 5 mM β-mercaptoethanol. |
Symbol | GHS07 |
Signal word | Warning |
Hazard statements | H317 - H319 - H412 |
Precautionary statements | P273 - P280 - P305 + P351 + P338 - P333 + P313 - P337 + P313 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥95% (SDS-PAGE) |
Storage Temp. | −70°C |
UNSPSC | 12352200 |