TAF1 (1371-1496) GST tag human
SIGMA/SRP6577 - recombinant, expressed in E. coli, ≥95% (SDS-PAGE)
Synonym: BA2R; CCG1; CCGS; DYT3; KAT4; NSCL2; TAF1 RNA Polymerase II; TAF2A; TAFII250; TATA Box Binding Protein (TBP)-Associated Factor; XDP
Product Type: Chemical
Immunoblotting TAF1(1371-1496 aa) (GST-tagged) Cat. No. SRP6577, SDS PAGE of human recombinant TAF1 bromodomain 1. Lanes 1. Marker 2.TAF1 (2 μg) 3. TAF1 (4 μg) 4. TAF1 (8 μg)
| assay | ≥95% (SDS-PAGE) |
| biological source | human |
| form | liquid |
| mol wt | 41.7 kDa (1371-1496 aa + NT GST Tag) |
| packaging | pkg of 100 μg |
| pkg of 20 μg | |
| recombinant | expressed in E. coli |
| shipped in | dry ice |
| storage temp. | −70°C |
| UniProt accession no. | P21675   |
| General description: | The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such as those on the N-terminal tails of histones. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as “readers” of histone acetylation marks regulating the transcription of target promoters. TAF1 is a component of transcription factor IID, and binds to core promoter sequences at the transcription start site. TAF1 helps control transcription by both its kinase and histone acetyltransferase enzymatic activities. It interacts with transcriptional activators such as the androgen receptor to promote transcription. Disruption of TAF1 causes dystonia 3 (X-linked torsion dystonia) and decreased apoptosis. This protein product contains the first bromodomain of TAF1. |
| Physical form: | 50 mM Tris, pH 7.5, containing 500 mM sodium chloride, 5 mM β-mercaptoethanol and 5% glycerol. |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H317 - H319 - H412 |
| Precautionary statements | P273 - P280 - P305 + P351 + P338 - P333 + P313 - P337 + P313 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥95% (SDS-PAGE) |
| Storage Temp. | −70°C |
| UNSPSC | 12352200 |