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DNA Methyl transferase 3L (160-387) human

SIGMA/SRP6582 - recombinant, expressed in E. coli, ≥95% (SDS-PAGE)

Synonym: DNMT3-Like Protein; DNMT3L

Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SRP6582-10UG 10 µg
 $0.00
1/EA
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Immunoblotting DNA Methyltransferase 3L (160-387 aa) Cat. No. SRP6582, SDS PAGE of human recombinant DNA Methyltransferase 3L. Lanes 1. Marker 2. DNMT3L (4 μg) 3. DNMT3L (2 μg) 4. DNMT3L (1 μg)

 

assay ≥95% (SDS-PAGE)
biological source human
form liquid
mol wt 53.2 kDa (160-387 aa + NT GST Tag)
packaging pkg of 10 μg
recombinant expressed in E. coli
shipped in dry ice
storage temp. −70°C
UniProt accession no. Q9UJW3 
General description: The DNA methyltransferase 3 (DNMT3) family of DNMT proteins perform intial methylation of cytosines to form 5-methylcytosine at CpG (cytosine-phosphate-guanine) sites on the DNA. Once methylation is established on DNA, DNMT1 protein is responsible for maintaining the CpG methylation pattern during chromosome replication. The DNMT3 family includes the two active members, DNMT3a and DNMT3b, and the regulatory factor DNMT3-like protein (DNMT3L). DNMT3L contains a cysteine-rich, DNMT3/ATRX homology or ATRX-DNMT3-DNMT3L (ADD) domain; however it lacks the proline-tryptophan-tryptophan-proline (PWWP) domain, required for non-specific DNA binding. The ADD domain of DNMT3L is responsible for specifically binding to unmethylated histone H3 lysine 4 (H3K4me0). DNMT3L also lacks the conserved residues in the C-terminal DNA MTase domain of DNMT3a and 3b that are required for activity. However, DNMT3L is required to stimulate the DNA methylation activity of DNMT3a and 3b through interactions with the catalytic domain of DNMT3a and 3b.
Physical form: 50 mM Tris, pH 8.0, containing 150 mM sodium chloride and 20% glycerol.
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥95% (SDS-PAGE)
Storage Temp. −70°C
UNSPSC 12352200

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