RIZ1 (2-200) GST tag human
SIGMA/SRP6588 - recombinant, expressed in E. coli, ≥95% (SDS-PAGE)
Synonym: KMT8; PR Domain Zinc Finger Protein 2; PRDM2; Retinoblastoma Protein-interacting Zinc Finger Protein
Product Type: Chemical
Immunoblotting RIZ1 (2-200 aa) (GST-tagged) Cat. No. SRP6588, SDS PAGE of human recombinant RIZ1. Lanes 1. Marker 2. RIZ (5 μg) 3. RIZ (2.5 μg)
| assay | ≥95% (SDS-PAGE) |
| biological source | human |
| form | liquid |
| mol wt | 49.5 kDa (2-200 aa + NT GST Tag) |
| packaging | pkg of 100 μg |
| pkg of 50 μg | |
| recombinant | expressed in E. coli |
| shipped in | dry ice |
| storage temp. | −70°C |
| UniProt accession no. | Q13029   |
| General description: | Retinoblastoma protein-interacting zinc finger protein 1 (RIZ1), also known as PRDM2, is a SAM-dependent histone methyltransferase that specifically methylates histone H3 on lysine 9. RIZ1 contains 8 zinc-finger motifs and 1 PR domain. The RIZ gene encodes two different proteins, RIZ1 and RIZ2. RIZ1 is a tumor suppressor that can arrest the cell cycle and induce apoptosis. RIZ2 however, is a proto-oncoprotein lacking the N-terminal PR domain containing the methyltransferase activity. When RIZ1 is silenced or mutated, the reduced methyltransferase activity can lead to inheritable changes in chromatin methylation and gene expression patterns. |
| Physical form: | 50 mM Tris, pH 7.5, containing 150 mM sodium chloride and 20% glycerol. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥95% (SDS-PAGE) |
| Storage Temp. | −70°C |
| UNSPSC | 12352200 |