Core Histones human
SIGMA/SRP6590 - ≥95% (SDS-PAGE)
Synonym: HeLa Core Histones
Product Type: Chemical
assay | ≥95% (SDS-PAGE) |
biological source | human |
concentration | 1 mg/mL |
form | liquid |
packaging | pkg of 50 and 100 μg |
shipped in | dry ice |
storage temp. | −70°C |
General description: | A nucleosome is the basic repeating unit of chromatin in which 146 base pairs of DNA wrap twice around a histone octamer consisting of two copies of each of the core histones, H2A, H2B, H3, and H4. The combination of two H2A/H2B dimers and one H3/H4 tetramer create the nucleosome core. Further, histone H1 combines with these histones to form 30nm fibers. These fibers have six nucleosomes per turn in a solenoid arrangement. Histone H3 undergoes many modifications which include acetylation, methylation, and phosphorylation that are important for regulation of gene transcription. |
Physical form: | 50 mM sodium phosphate, pH 6.9, containing 10 mM sodium chloride and 1 mM β-mercaptoethanol. |
Symbol | GHS07 |
Signal word | Warning |
Hazard statements | H317 - H319 |
Precautionary statements | P280 - P302 + P352 - P305 + P351 + P338 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥95% (SDS-PAGE) |
Storage Temp. | −70°C |
UNSPSC | 12352200 |