Core Histones human
SIGMA/SRP6590 - ≥95% (SDS-PAGE)
Synonym: HeLa Core Histones
Product Type: Chemical
Immunoblotting Core Histones, Human Cat. No. SRP6590, SDS PAGE of Human Core Histones. Lanes 1. Marker 2. Core Histones (1 μg) 3. Core Histones (2 μg)
| assay | ≥95% (SDS-PAGE) |
| biological source | human |
| concentration | 1 mg/mL |
| form | liquid |
| packaging | pkg of 50 and 100 μg |
| shipped in | dry ice |
| storage temp. | −70°C |
| technique(s) | cell based assay: suitable |
| General description: | A nucleosome is the basic repeating unit of chromatin in which 146 base pairs of DNA wrap twice around a histone octamer consisting of two copies of each of the core histones, H2A, H2B, H3, and H4. The combination of two H2A/H2B dimers and one H3/H4 tetramer create the nucleosome core. Further, histone H1 combines with these histones to form 30nm fibers. These fibers have six nucleosomes per turn in a solenoid arrangement. Histone H3 undergoes many modifications which include acetylation, methylation, and phosphorylation that are important for regulation of gene transcription. |
| Physical form: | 50 mM sodium phosphate, pH 6.9, containing 10 mM sodium chloride and 1 mM β-mercaptoethanol. |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H317 - H319 |
| Precautionary statements | P280 - P302 + P352 - P305 + P351 + P338 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥95% (SDS-PAGE) |
| Storage Temp. | −70°C |
| UNSPSC | 12352200 |