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ErbB4/HER4 HIS tag human

SIGMA/SRP6594 - recombinant, expressed in E. coli, ≥95% (SDS-PAGE)

Synonym: MGC138404; p180erbB4

Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SRP6594-5UG 5 µg
 $0.00
1/EA
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assay ≥95% (SDS-PAGE)
biological source human
form lyophilized
mol wt 5.8 kDa
packaging pkg of 5 μg
recombinant expressed in E. coli
shipped in dry ice
storage temp. −70°C
tag His tagged
UniProt accession no. P01308 
General description: Akt3 or Protein Kinase B γ (PKB) is a serine/threonine kinase that is a member of the Akt family. In mammals, the Akt family comprises of three highly homologous members known as Akt1 (PKB), Akt2 (PKB), and Akt 3. Akt 3 like the other family members is activated in cells exposed to diverse stimuli such as hormones, growth factors, and extracellular matrix components. The activation mechanism remains to be fully characterized but occurs downstream of phosphoinositide 3-kinase (PI3K). PI3K generates phosphatidylinositol-3,4,5-trisphosphate (PIP3), a lipid second messenger essential for the translocation of Akt family members to the plasma membrane where they are phosphorylated and activated by phosphoinositide-dependent kinase-1 (PDK-1) and phosphoinositide-dependent kinase-2 (PDK-2 possibly ILK). Akt 3 like the other family members phosphorylates and regulates the function of many cellular proteins involved in processes that include cellular metabolism, survival/apoptosis, and proliferation. Recent evidence indicates that Akt 3 is frequently overexpressed in many types of human cancers including breast and prostate. Although the mechanisms have not yet been fully characterized, increased expression and activation of Akt is believed to promote cell proliferation and survival thereby contributing to cancer progression.
Physical form: Sterile filtered white lyophilized (freeze-dried) powder. The protein was lyophilized from 50mM Sodium Chloride solution.
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥95% (SDS-PAGE)
Storage Temp. −70°C
UNSPSC 12352200

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