IL-22 human
SIGMA/SRP6595 - recombinant, expressed in HEK 293 cells (Ala 34 - Ile 179), ≥95% (SDS-PAGE)
Synonym: IL-TIF; ZCYTO18
Product Type: Chemical
| assay | ≥95% (SDS-PAGE) |
| biological source | human |
| form | lyophilized powder |
| impurities | <1 EU/μg (LAL test) |
| mol wt | calculated mol wt 17.6 kDa (a polyhistidine tag at the N-terminus.) |
| observed mol wt 21-33 kDa (DTT-reduced protein.Protein migrates as 21-33 kDa in a SDS-PAGE due to glycosylation. ) |
|
| packaging | pkg of 10 μg |
| recombinant | expressed in HEK 293 cells (Ala 34 - Ile 179) |
| shipped in | wet ice |
| storage temp. | −20°C |
| tag | His tagged |
| UniProt accession no. | Q9GZX6   |
| General description: | Interleukin-22 (IL22) is also known as cytokine Zcyto18, IL-10-related T-cell-derived-inducible factor (IL-TIF), which is belongs to the IL-10 family or IL-10 superfamily (including IL-19, IL-20, IL-24, and IL-26), a class of potent mediators of cellular inflammatory responses. IL-22 is produced by activated DC and T cells and initiates innate immune responses against bacterial pathogens especially in epithelial cells such as respiratory and gut epithelial cells. IL-22 biological activity is initiated by binding to a cell-surface complex composed of IL-22R1 and IL-10R2 receptor chains and further regulated by interactions with a soluble binding protein IL-22BP. IL-22 also promotes hepatocyte survival in the liver and epithelial cells in the lung and gut similar to IL-10. |
| Physical form: | Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Generally Mannitol or trehalose is added as a protectant before lyophilization. |
| Reconstitution: | Centrifuge the vial prior to opening. Reconstitute in sterile deionized water to a concentration of 100 μg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C. |
| Purity | ≥95% (SDS-PAGE) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |