Calreticulin human
SIGMA/SRP8001 - recombinant, expressed in E. coli, His tagged, >90% (SDS-PAGE)
Synonym: CRP55; Calregulin; ERp60; Endoplasmic reticulum resident protein 60; grp60
Product Type: Chemical
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| assay | >90% (SDS-PAGE) |
| biological source | human |
| form | liquid |
| impurities | <1 EU/μg endotoxin, tested |
| mol wt | ~55 kDa by SDS-PAGE |
| packaging | pkg of 10 μg |
| recombinant | expressed in E. coli |
| shipped in | wet ice |
| storage condition | avoid repeated freeze/thaw cycles |
| storage temp. | −20°C |
| tag | His tagged |
| technique(s) | calcium flux assay: suitable |
| UniProt accession no. | P27797   |
| Application: | Human calreticulin has been used in a study to determine the effects of uncoupling protein 4 (UCP4) on the expression of proteins in the store-operated Ca2+ entry pathway. |
| Biochem/physiol Actions: | Calreticulin is involved in regulation of intracellular Ca2+ homoeostasis and ER Ca2+ capacity. It constitutes together with calnexin and ERp57 the ′calreticulin/calnexin cycle′ that is responsible for folding and quality control of newly synthesized glycoproteins. Calreticulin has been implicated to play a role in many biological systems, including functions inside and outside the ER, indicating that the protein is a multi-process molecule. Recently, Calreticulin was shown to enhance the merger of macrophages and tumor cells, increasing phagocytosis. |
| General description: | Calreticulin (CALR) is expressed in the endoplasmic reticulum. The gene encoding it is localized on human chromosome 19p13.13. |
| Other Notes: | Human calreticulin (aa18-417) is fused at the C-terminus to a His-tag. |
| Physical form: | Solution in 55 mM TRIS-HCl, pH 8.2, containing 150 mM NaCl. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | >90% (SDS-PAGE) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |