GITRL, Soluble mouse
SIGMA/SRP8009 - recombinant, expressed in HEK 293 cells, FLAG® tagged, >90% (SDS-PAGE)
Synonym: AITRL; EGF-like protein 9; Glucocorticoid-
Product Type: Chemical
| assay | >90% (SDS-PAGE) |
| biological source | mouse |
| color | clear |
| concentration | ≥0.2 mg/mL |
| form | liquid |
| impurities | <0.1 EU/μg endotoxin, tested |
| mol wt | ~22 kDa by SDS-PAGE |
| packaging | pkg of 50 μg |
| recombinant | expressed in HEK 293 cells |
| shipped in | wet ice |
| storage condition | avoid repeated freeze/thaw cycles |
| storage temp. | −20°C |
| tag | FLAG® tagged |
| UniProt accession no. | Q7TS55   |
| General description: | GITRL (Glucocorticoid-induced TNF receptor ligand) is expressed on dendritic cells (DC), monocytes, macrophages, B cells, activated T cells, endothelial cells, osteoclasts and various healthy non-lymphoid tissues (e.g. testis). GITRL is constitutively expressed and released as soluble form by solid tumors and various hematopoietic malignancies. GITRL causes differentiation of osteoclasts, activation of macrophages, but also alteration of carcinoma and leukemia cells and influences apoptosis. Binding to GITR is important in regulating T cell proliferation and TCR-mediated apoptosis. GITRL is implicated in development of autoimmune diseases and in the immune response against infectious pathogens and tumors. |
| Legal Information: | FLAG is a registered trademark of Sigma-Aldrich Co. LLC |
| Other Notes: | The extracellular domain of mouse GITRL (aa 45-173) is fused at the N-terminus to a FLAG®-tag. |
| Physical form: | Solution in 10 mM glycine, pH 10.0. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | >90% (SDS-PAGE) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |