GPX1 human
SIGMA/SRP8010 - recombinant, expressed in E. coli, His tagged, >90% (SDS-PAGE)
Synonym: Cellular glutathione peroxidase; Death receptor 6; GSHPx-1; Glutathione peroxidase 1
CAS Number: 1451392-36-1
Product Type: Chemical
| assay | >90% (SDS-PAGE) |
| biological source | human |
| color | white |
| form | lyophilized |
| impurities | <1 EU/μg endotoxin, tested |
| mol wt | ~25 kDa by SDS-PAGE |
| packaging | pkg of 10 μg |
| recombinant | expressed in E. coli |
| shipped in | wet ice |
| storage condition | avoid repeated freeze/thaw cycles |
| storage temp. | −20°C |
| tag | His tagged |
| UniProt accession no. | P07203   |
| Biochem/physiol Actions: | GPX1 (glutathione peroxidase 1) is responsible for scavenging free radicals and derivatives. GPXs reduces lipid hydroperoxides to the corresponding alcohols as well as free hydrogen peroxide to water. Mutations in the GPX1 gene are associated with nonalcoholic fatty liver disease (NAFLD) susceptibility. Mutation in GPX1 at C594T is linked with oxidative stress-associated disorders, including prostate cancer and bladder cancer. |
| General description: | GPX1 (glutathione peroxidase 1) is a selenoprotein and the gene is mapped to human chromosome 3p21.3. It is present in the cytoplasm and is widely expressed. |
| Other Notes: | Human GPX1 (aa 1-201) is fused at the C-terminus to a His-tag. |
| Physical form: | Lyophilized from 55 mM TRIS-HCl, pH 8.2, containing 150 mM NaCl, 1 mM DTT. |
| Reconstitution: | Reconstitute with 100 μL deionized water. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | >90% (SDS-PAGE) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |