Jagged-2 (human): FC (human)
SIGMA/SRP8013 - recombinant, expressed in HEK 293 cells, >90% (SDS-PAGE)
Synonym: Alpha-
Product Type: Chemical
assay | >90% (SDS-PAGE) |
biological source | human |
color | white |
form | liquid |
impurities | <0.1 EU/μg endotoxin, tested |
mol wt | ~150 kDa by SDS-PAGE |
packaging | pkg of 10 μg |
recombinant | expressed in HEK 293 cells |
shipped in | wet ice |
storage temp. | −20°C |
UniProt accession no. | Q9Y219 |
General description: | Jagged-2 is a putative Notch ligand involved in the mediation of Notch signaling, that can induce stromal cells to secrete IL-6, VEGF and IGF-1. Notch activation can interact with NF-kappaB and C-myc to promote the proliferation and to inhibit the apoptosis of MM cells, showing in the relationship between the incidence of myeloma and drug resistance. Jagged-2 is also involved in limb development. |
Other Notes: | Human Jagged-2 (aa 1-1054) is fused at the C-terminus to the Fc portion of human IgG. |
Physical form: | Solution in PBS. |
RIDADR | NONH for all modes of transport |
Purity | >90% (SDS-PAGE) |
Storage Temp. | −20°C |
UNSPSC | 12352200 |