Progranulin human
SIGMA/SRP8014 - recombinant, expressed in HEK 293 cells, untagged, >95% (SDS-PAGE)
Synonym: Activation-inducible TNF-related ligand; PEPI; Proepithelin
Product Type: Chemical
| assay | >95% (SDS-PAGE) |
| biological source | human |
| color | white |
| conjugate | untagged |
| form | lyophilized |
| impurities | <0.1 EU/μg endotoxin, tested |
| mol wt | ~65 kDa by SDS-PAGE |
| packaging | pkg of 10 μg |
| recombinant | expressed in HEK 293 cells |
| shipped in | wet ice |
| storage condition | avoid repeated freeze/thaw cycles |
| storage temp. | −20°C |
| UniProt accession no. | P28799   |
| Biochem/physiol Actions: | Progranulin (PGRN) is a widely expressed pluripotent growth factor, which plays a crucial role in various processes such as development, cell cycle progression, cell motility, wound repair and inflammation. Additionally, It is also implicated in early embryogenesis, host defense, cartilage development and degradation. Mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). PGRN expression is associated with the development of various type of cancer such as breast cancer, ovarian carcinoma, and multiple myeloma. Overexpression of PGRN has been observed in neurodegenerative diseases such as microglia of Creutzfeldt-Jacob patients and in spinal cord of amyotrophic lateral sclerosis (ALS) patients. |
| General description: | Progranulin (PGRN) is a cysteine-rich protein with 593-amino acids and has a molecular weight of ~68.5kDa. The PGRN gene, with one non-coding exon and 12 coding exons spanning 8kb of genomic DNA, is mapped to human chromosome 17q21. The encoded protein is characterized by seven granulin-like domains, which include 7.5 highly conserved tandem repeats of a rare 12 cysteinyl residues. PGRN is predominantly expressed in rapidly cycling epithelial cells, leukocytes, neurons, and chondrocytes. |
| Other Notes: | Signal peptide and human progranulin (aa 1-593) is untagged. Reflects the native sequence with no additional aa. |
| Physical form: | Lyophilized from 0.2 μm-filtered solution in PBS. |
| Reconstitution: | Reconstitute with 100 μL deionized water. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | >95% (SDS-PAGE) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |