PARG human
SIGMA/SRP8023 - recombinant, expressed in Sf21 cells, His tagged, >95% (SDS-PAGE)
Synonym: FNDC5 (cleaved); Poly(ADP-ribose) glycohydrolase
CAS Number: 9068-16-0
Product Type: Chemical
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| assay | >95% (SDS-PAGE) |
| biological source | human |
| color | clear |
| concentration | ≥0.2 mg/mL |
| form | liquid |
| mol wt | ~110 kDa by SDS-PAGE |
| packaging | pkg of 2 μg |
| recombinant | expressed in Sf21 cells |
| shipped in | dry ice |
| solubility | water: soluble |
| storage temp. | −70°C |
| tag | His tagged |
| technique(s) | cell based assay: suitable |
| UniProt accession no. | Q86W56   |
| Application: | PARG human has been used in the digestion of sciatic nerve sections, in co-immunoprecipitation, in in vitro glycohydrolase activity assay |
| Biochem/physiol Actions: | Poly(ADP-ribose) glycohydrolase(PARG) hydrolyzes poly(ADP-ribose) at glycosidic(1′′-2′′) linkage of ribose-ribose bond to produce free ADP-ribose. It is an endo- and exo-glycosidase. PARG plays arole in DNA repair and replication. Inhibited or depleted PARG in cells aremore prone to DNA-damaging agents. PARG also averts the accumulation of PAR inthe cytoplasm and parthanatos, a caspase-independent PAR-mediated type of celldeath. |
| General description: | Research area: Cell signaling |
| Other Notes: | Human PARG is fused to a His-tag. |
| Physical form: | Solution in 50 mM TRIS-HCl, pH 7.5, containing 100 mM sodium chloride, 0.2% NP-40, 50 mM imidazole and 10% glycerol. |
| Symbol |  GHS08 |
| Signal word | Danger |
| Hazard statements | H360D |
| Precautionary statements | P201 - P202 - P280 - P308 + P313 - P405 - P501 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | >95% (SDS-PAGE) |
| Storage Temp. | −70°C |
| UNSPSC | 12352200 |