Annexin V human
SIGMA/SRP8026 - recombinant, expressed in E. coli, GST tagged, ≥95% (SDS-PAGE)
Synonym: Annexin A5; Calphobindin I; EC 2.7.1.23; Endonexin II; Placental anticoagulantprotein I
Product Type: Chemical
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| assay | ≥95% (SDS-PAGE) |
| biological source | human |
| color | white |
| form | lyophilized |
| mol wt | ~52 kDa |
| packaging | pkg of 100 μg |
| recombinant | expressed in E. coli |
| shipped in | wet ice |
| storage condition | avoid repeated freeze/thaw cycles |
| storage temp. | −20°C |
| tag | GST tagged |
| technique(s) | activity assay: suitable |
| UniProt accession no. | P08758   |
| Application: | Annexin V has been used to examine phosphorylation activity of ChaK1 (channel-kinase 1). |
| Biochem/physiol Actions: | Annexins are a family of water-soluble proteins that bind to membranes and phospholipids in a calcium-dependent manner. They participate in several cellular functions, such as membrane fusion and cytoskeletal interaction. Annexin V is a potent anticoagulant and serves as a voltage-gated calcium channel when bound to membrane in vitro. It is found to inhibit phospholipase A2 and protein kinase C. |
| General description: | Annexin V is a member of the annexin family of calcium and membrane-binding proteins that have anticoagulatory and anti-inflammatory properties. The encoded protein is 320 amino acid long and is folded into four domains, each having five α-helices, forming a superhelical globular structure. The ANX5 gene is mapped to human chromosome 4q26-q28 and spans a length of 28kb containing 13 exons and 12 introns. |
| Other Notes: | Recombinant human annexin V fused to a GST-tag. |
| Physical form: | Lyophilized from PBS, pH 7.4. |
| Preparation Note: | Reconstitute with 100 μL deionized water. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥95% (SDS-PAGE) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |