Annexin V human
SIGMA/SRP8026 - recombinant, expressed in E. coli, GST tagged, ≥95% (SDS-PAGE)
Synonym: Annexin A5; Calphobindin I; EC 2.7.1.23; Endonexin II; Placental anticoagulantprotein I
Product Type: Chemical
assay | ≥95% (SDS-PAGE) |
biological source | human |
color | white |
form | lyophilized |
mol wt | ~52 kDa |
packaging | pkg of 100 μg |
recombinant | expressed in E. coli |
shipped in | wet ice |
storage condition | avoid repeated freeze/thaw cycles |
storage temp. | −20°C |
tag | GST tagged |
technique(s) | activity assay: suitable |
UniProt accession no. | P08758 |
Application: | Annexin V has been used to examine phosphorylation activity of ChaK1 (channel-kinase 1). |
Biochem/physiol Actions: | Annexins are a family of water-soluble proteins that bind to membranes and phospholipids in a calcium-dependent manner. They participate in several cellular functions, such as membrane fusion and cytoskeletal interaction. Annexin V is a potent anticoagulant and serves as a voltage-gated calcium channel when bound to membrane in vitro. It is found to inhibit phospholipase A2 and protein kinase C. |
General description: | Annexin V is a member of the annexin family of calcium and membrane-binding proteins that have anticoagulatory and anti-inflammatory properties. The encoded protein is 320 amino acid long and is folded into four domains, each having five α-helices, forming a superhelical globular structure. The ANX5 gene is mapped to human chromosome 4q26-q28 and spans a length of 28kb containing 13 exons and 12 introns. |
Other Notes: | Recombinant human annexin V fused to a GST-tag. |
Physical form: | Lyophilized from PBS, pH 7.4. |
Reconstitution: | Reconstitute with 100 μL deionized water. |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥95% (SDS-PAGE) |
Storage Temp. | −20°C |
UNSPSC | 12352200 |