DR6 (human): FC (human)
SIGMA/SRP8028 - recombinant, expressed in HEK 293 cells, >95% (SDS-PAGE)
Synonym: CD358; TNFRSF21; Tumor necrosis factor receptor superfamily member 21
Product Type: Chemical
assay | >95% (SDS-PAGE) |
biological source | human |
color | white |
form | lyophilized |
impurities | <0.1 EU/μg endotoxin, tested |
mol wt | ~80 kDa by SDS-PAGE |
packaging | pkg of 50 μg |
recombinant | expressed in HEK 293 cells |
shipped in | wet ice |
storage condition | avoid repeated freeze/thaw cycles |
storage temp. | −20°C |
UniProt accession no. | O75509 |
General description: | DR6 is an orphan TNF receptor superfamily member belonging to a subgroup of receptors called death receptors. Expressed ubiquitously with high expression in lymphoid organs, heart, brain, and pancreas. Broadly expressed by developing neurons where it functions as pro-apoptotic factor. Recently, it has been reported that interaction with the beta-amyloid precursor protein (APP) activates a widespread caspase-dependent self-destruction program dependent on caspase-6. |
Other Notes: | The Fc portion of human IgG1 is fused to the C-terminus of human DR6 (aa 42-351). |
Physical form: | Lyophilized from PBS. |
Reconstitution: | Reconstitute with 50 μL deionized water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein. |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | >95% (SDS-PAGE) |
Storage Temp. | −20°C |
UNSPSC | 12352200 |