Fn14 (human): FC (human)
SIGMA/SRP8030 - recombinant, expressed in HEK 293 cells, >95% (SDS-PAGE)
Synonym: CD266; E1A-associated protein p300; FGF-inducible 14; Tumor necrosis factor receptor superfamily member 12A
Product Type: Chemical
assay | >95% (SDS-PAGE) |
biological source | human |
color | white |
form | lyophilized |
impurities | <0.1 EU/μg endotoxin, tested |
mol wt | ~35 kDa by SDS-PAGE |
packaging | pkg of 50 μg |
recombinant | expressed in HEK 293 cells |
shipped in | wet ice |
storage condition | avoid repeated freeze/thaw cycles |
storage temp. | −20°C |
UniProt accession no. | Q9NP84 |
General description: | TWEAK is a cytokine that controls proliferation, migration, differentiation, apoptosis, angiogenesis and inflammation. TWEAK binds to Fn14, a highly inducible cell-surface receptor that is linked to several intracellular signalling pathways, including the nuclear factor-B (NF-kappaB) pathway. The TWEAK-Fn14 axis plays a beneficial role in tissue repair following acute injury and may contribute to cancer, chronic autoimmune diseases and acute ischaemic stroke. |
Other Notes: | The extracellular region of human FN14 (aa 28-75) is fused at the C-terminus to the Fc portion of human IgG1. |
Physical form: | Lyophilized from PBS. |
Reconstitution: | Reconstitute with 50 μL deionized water. |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | >95% (SDS-PAGE) |
Storage Temp. | −20°C |
UNSPSC | 12352200 |