Fn14 (human): FC (human)
SIGMA/SRP8030 - recombinant, expressed in HEK 293 cells, >95% (SDS-PAGE)
Synonym: CD266; E1A-associated protein p300; FGF-inducible 14; Tumor necrosis factor receptor superfamily member 12A
Product Type: Chemical
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| assay | >95% (SDS-PAGE) |
| biological source | human |
| color | white |
| form | lyophilized |
| impurities | <0.1 EU/μg endotoxin, tested |
| mol wt | ~35 kDa by SDS-PAGE |
| packaging | pkg of 50 μg |
| recombinant | expressed in HEK 293 cells |
| shipped in | wet ice |
| storage condition | avoid repeated freeze/thaw cycles |
| storage temp. | −20°C |
| UniProt accession no. | Q9NP84   |
| General description: | TWEAK is a cytokine that controls proliferation, migration, differentiation, apoptosis, angiogenesis and inflammation. TWEAK binds to Fn14, a highly inducible cell-surface receptor that is linked to several intracellular signalling pathways, including the nuclear factor-B (NF-kappaB) pathway. The TWEAK-Fn14 axis plays a beneficial role in tissue repair following acute injury and may contribute to cancer, chronic autoimmune diseases and acute ischaemic stroke. |
| Other Notes: | The extracellular region of human FN14 (aa 28-75) is fused at the C-terminus to the Fc portion of human IgG1. |
| Physical form: | Lyophilized from PBS. |
| Preparation Note: | Reconstitute with 50 μL deionized water. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | >95% (SDS-PAGE) |
| Storage Temp. | −20°C |
| UNSPSC | 51111800 |