FNDC5
SIGMA/SRP8031 - recombinant, expressed in E. coli, untagged, >95% (SDS-PAGE)
Synonym: Fibronectin type III domain-containing protein 5; Fibronectin type III repeat-containing protein 2
Product Type: Chemical
| assay | >95% (SDS-PAGE) |
| color | white |
| conjugate | untagged |
| form | lyophilized |
| impurities | <0.01 EU/μg endotoxin, tested |
| mol wt | ~16 kDa |
| packaging | pkg of 10 μg |
| recombinant | expressed in E. coli |
| shipped in | wet ice |
| storage temp. | −20°C |
| UniProt accession no. | Q8NAU1   |
| General description: | Irisin is a recently described exercise-induced hormone secreted by skeletal muscle in mice and humans. Irisin activates beige fat cells (beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone irisin). Irisin is cleaved from the type I membrane protein FNDC5 and improves systemic metabolism by increasing energy expenditure. |
| Other Notes: | FNDC5 (extracellular domain, human (aa 32-152) / mouse (aa 29-149)) is untagged. FNDC5 extracellular domain has 100% identity between human, mouse and rat. |
| Physical form: | Lyophilized from PBS. |
| Reconstitution: | Reconstitute with 100 μL deionized water. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | >95% (SDS-PAGE) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |