IL-36α mouse
SIGMA/SRP8035 - recombinant, expressed in E. coli, untagged, >95% (SDS-PAGE)
Synonym: Interleukin-1 family member 6; Interleukin-1 homolog 1; Interleukin-1α; Interleukin-36α
Product Type: Chemical
assay | >95% (SDS-PAGE) |
biological source | mouse |
conjugate | untagged |
form | lyophilized |
impurities | <0.01 EU/μg endotoxin, tested |
mol wt | ~17 kDa |
packaging | pkg of 10 μg |
recombinant | expressed in E. coli |
shipped in | wet ice |
storage temp. | −20°C |
UniProt accession no. | Q9JLA2 |
General description: | IL-36α (IL-1F6), IL-36β (IL-1F8) and IL-36γ (IL-1F9) bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1. IL-36Ra inhibits the production of proinflammatory cytokines, including IL-12, IL-1β, IL-6, TNF-α and IL-23 induced by IL-36 in BMDC and CD4 T cells. Skin and dendritic cells are targets of the IL-36 interleukins leading to a Th1 response. These cytokines may represent potential targets for immune-mediated inflammatory conditions or, alternatively, could be used as adjuvants in vaccination. |
Other Notes: | IL-36alpha (mouse) (aa 8-160) is untagged. |
Physical form: | Lyophilized from PBS. |
Reconstitution: | Reconstitute with 100 μL deionized water. |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 2 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | >95% (SDS-PAGE) |
Storage Temp. | −20°C |
UNSPSC | 12352200 |