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APRIL, Soluble mouse

SIGMA/SRP8043 - recombinant, expressed in HEK 293 cells, FLAG® tagged, >95% (SDS-PAGE)

Synonym: ACRP30headless:A-proliferation-inducing ligand; ACRP30headless:APRIL; ACRP30headless:CD256; TNFSF10

Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SRP8043-10UG 10 µg
 $463.00
1/EA		 Add To Favorites
assay >95% (SDS-PAGE)
biological source mouse
color white
form lyophilized
impurities <0.02 EU/μg endotoxin, tested
mol wt ~34 kDa by SDS-PAGE
packaging pkg of 10 μg
recombinant expressed in HEK 293 cells
shipped in wet ice
storage condition avoid repeated freeze/thaw cycles
storage temp. −20°C
tag FLAG® tagged
UniProt accession no. Q9D777 
General description: APRIL is a cytokine that belongs to the TNF superfamily and binds to TACI and BCMA. It is implicated in the regulation of tumor cell growth, is involved in monocyte/macrophage-mediated immunological processes and functions as an important survival factor for plasmablasts and bone marrow plasma cells. APRIL is a high activity construct in which two trimeric APRIL ligands are artificially linked via the collagen domain of ACRP30. This construct very effectively stimulates proliferation B cell. A basic amino acid sequence (QKQKKQ) close to the N-terminus of APRIL is required for binding to negatively charged sulfated glycosaminoglycan side chains of proteoglycans. Proteoglycans mediate binding of APRIL to tumor cells as well as primary lymphoid cells.
Legal Information: FLAG is a registered trademark of Sigma-Aldrich Co. LLC
Other Notes: The extracellular domain of mouse APRIL (aa 88-232) is fused at the N-terminus to mouse ACRP30headless (aa 18-110) and a FLAG®-tag.
Physical form: Lyophilized from PBS.
Reconstitution: Reconstitute with 100 μL deionized water.
RIDADR NONH for all modes of transport
WGK Germany WGK 2
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity >95% (SDS-PAGE)
Storage Temp. −20°C
UNSPSC 12352200

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