CD40L, Soluble human
SIGMA/SRP8044 - recombinant, expressed in CHO cells, FLAG® tagged, >95% (SDS-PAGE)
Synonym: ACRP30headless:CD154; ACRP30headless:CD40L; ACRP30headless:TNFSF5; ADIPOQ-CD40L
Product Type: Chemical
assay | >95% (SDS-PAGE) |
biological source | human |
form | lyophilized |
impurities | <0.01 EU/μg endotoxin, tested |
mol wt | 35-40 kDa by SDS-PAGE |
packaging | pkg of 10 μg |
recombinant | expressed in CHO cells |
shipped in | wet ice |
storage condition | avoid repeated freeze/thaw cycles |
storage temp. | −20°C |
tag | FLAG® tagged |
UniProt accession no. | P29965 |
Biochem/physiol Actions: | CD40L (cluster of differentiation 40 ligand) is active in its membrane-bound form. It interacts with CD40 and functions as a proinflammatory and procoagulant agent. The serum levels of soluble CD40L is elevated in malignant middle cerebral artery infarction (MMCAI) patients, especially in non-surviving patients. |
General description: | CD40L (cluster of differentiation 40 ligand) belongs to the tumor necrosis factor (TNF) family, and is expressed by basophils, B cells, monocytic cells, natural killer cells, platelets, mast cells and T cells. It is predominantly expressed on pro-inflammatory T cells. It also exists in a soluble form. |
Legal Information: | FLAG is a registered trademark of Sigma-Aldrich Co. LLC |
Other Notes: | Human CD40L (aa 116-261) is fused at the N-terminus to mouse ACRP30headless (aa 18-111) and a FLAG®-tag. |
Physical form: | Lyophilized from PBS |
Reconstitution: | Reconstitute with 100 μL deionized water. |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 2 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | >95% (SDS-PAGE) |
Storage Temp. | −20°C |
UNSPSC | 12352200 |