CD279 (human): FC (human)
SIGMA/SRP8052 - recombinant, expressed in CHO cells, ≥98% (SDS-PAGE)
Synonym: Hepatitis A virus cellular receptor 2; PD-1; Programmed cell death protein 1
Product Type: Chemical
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| assay | ≥98% (SDS-PAGE) |
| biological source | human |
| form | lyophilized |
| impurities | <0.06 EU/μg endotoxin, tested |
| mol wt | monomer 46 kDa by calculation |
| packaging | pkg of 100 μg |
| recombinant | expressed in CHO cells |
| shipped in | wet ice |
| storage temp. | −20°C |
| UniProt accession no. | Q15116   |
| General description: | Programmed Death-1 (PD-1, CD279) is a type I transmembrane protein belonging to the CD28/CTLA-4 family of immunoreceptors that mediate signals for regulating immune responses. Members of the CD28/CTLA-4 family have been shown to either promote T cell activation (CD28 and ICOS) or downregulate T cell activation (CTLA-4 and PD-1). CD279 is expressed on activated T-cells, B-cells, myeloid cells and on a subset of thymocytes. In vitro, ligation of CD279 inhibits TCR-mediated T-cell proliferation and production of IL-1, IL-4, IL-10 and IFN-γ. In addition, CD279 ligation also inhibits BCR mediated signaling. CD279 deficient mice have a defect in peripheral tolerance and spontaneously develop autoimmune diseases. |
| Other Notes: | The extracellular domain of human CD279 [PD-1] (aa 25-167) is fused to the N-terminus of the Fc region of human IgG1. |
| Physical form: | Lyophilized from 0.2 μm-filtered solution in PBS. |
| Preparation Note: | Reconstitute at 100 μg/mL in sterile PBS. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (SDS-PAGE) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |