Tim-4 (human): FC (human)
SIGMA/SRP8058 - recombinant, expressed in CHO cells, ≥98% (SDS-PAGE)
Synonym: PC cell-derived growth factor; TIM4; TIMD4
Product Type: Chemical
| assay | ≥98% (SDS-PAGE) |
| biological source | human |
| color | white |
| form | lyophilized |
| impurities | <0.06 EU/μg endotoxin, tested |
| mol wt | monomer 54 kDa by calculation |
| packaging | pkg of 100 μg |
| recombinant | expressed in CHO cells |
| shipped in | wet ice |
| storage temp. | −20°C |
| UniProt accession no. | Q96H15   |
| General description: | The TIM (T cell/transmembrane, immunoglobulin and mucin) family plays a critical role in regulating immune responses, including allergy, asthma, transplant tolerance, autoimmunity and the response to viral infections. The unique structure of TIM immunoglobulin variable region domains allows highly specific recognition of phosphatidylserine (PtdSer), exposed on the surface of apoptotic cells. TIM-4 (T cell; immunoglobulin; Mucin-4), also known as SMUCKLER, is a 60 kDa member of the TIM family of immune regulating proteins. TIM-4 is exclusively expressed on antigen-presenting cells, where it mediates phagocytosis of apoptotic cells and plays an important role in maintaining tolerance. TIM-4 binds specifically to TIM-1 which is also the cellular receptor for the hepatitis A virus, and has been implicated in the development of asthma. Among hematopoietic cells, TIM-1 is expressed on activated B and T cells, preferentially in the Th2 subset of CD4+ T cells. The interaction of TIM-4 with TIM-1 induces costimulatory and hyperproliferative signals in T cells. |
| Other Notes: | The extracellular domain of mouse Tim-4 (aa 22-279) is fused to the N-terminus of the Fc region of human IgG1. |
| Physical form: | Lyophilized from 0.2 μm-filtered solution in PBS. |
| Reconstitution: | Reconstitute at 100 μg/mL in sterile PBS. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (SDS-PAGE) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |