Jagged-2 (human): FC (human)
SIGMA/SRP8059 - recombinant, expressed in HEK 293 cells, ≥90% (SDS-PAGE)
Synonym: Alpha-
Product Type: Chemical
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| assay | ≥90% (SDS-PAGE) |
| form | lyophilized |
| impurities | <0.1 EU/μgtested |
| mol wt | ~150 kDa by SDS-PAGE |
| recombinant | expressed in HEK 293 cells |
| shipped in | wet ice |
| storage temp. | −20°C |
| UniProt accession no. | Q9Y219   |
| General description: | Jagged-2 is a putative Notch ligand involved in the mediation of Notch signaling, that can induce stromal cells to secrete IL-6, VEGF and IGF-1. Notch activation can interact with NF-kappaB and C-myc to promote the proliferation and to inhibit the apoptosis of MM cells, showing in the relationship between the incidence of myeloma and drug resistance. Jagged-2 is also involved in limb development. |
| Other Notes: | Human Jagged-2 (aa 1-1054) is fused at the C-terminus to the Fc portion of human IgG. |
| Physical form: | Lyophilized. Contains PBS + 0.02 % CHAPS. |
| Preparation Note: | Reconstitute with 100μl sterile water. |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥90% (SDS-PAGE) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |