D-(+)-Trehalose dihydrate
SIGMA/T0167 - from Saccharomyces cerevisiae, powder, BioReagent, suitable for cell culture, suitable for insect cell culture, ≥99%
Synonym: α,α-Trehalose; α-D-Glucopyranosyl-α-D-glucopyranoside
CAS Number: 6138-23-4
Empirical Formula (Hill Notation): C12H22O11 · 2H2O
Molecular Weight: 378.33
EC Number: 202-739-6
MDL Number: MFCD00071594
Linear Formula: C12H22O11 · 2H2O
Product Type: Chemical
assay | ≥99% |
biological source | Saccharomyces cerevisiae |
form | powder |
InChI | 1S/C12H22O11.2H2O/c13-1-3 |
InChI key | DPVHGFAJLZWDOC-PVXXTIHASA |
product line | BioReagent |
Quality Level | 200 |
SMILES string | [H]O[H].[H]O[H].OC[C@H]1O |
solubility | H2O: 50 mg/mL |
technique(s) | cell culture | insect: suitable |
cell culture | mammalian: suitable |
Application: | D-(+)-Trehalose dihydrate has been used in a slow-freezing method for freezing rabbit oocytes. It has also been used in solid-surface vitrification (SSV) of in vitro-matured oocytes. It is suitable for use as a cryoprotectant in a variety of cell freezing media. |
Biochem/physiol Actions: | Trehalose is essential for embryogenesis, carbon metabolism, photosynthesis and flowering in plants. It predominantly exists among the species that supports anhydrobiosis (life without water). It serves as a carbohydrate reserve in microorganisms and protects them from adverse conditions, such as heat, cold, dehydration, desiccation and oxidation. Trehalose acts as a chemical chaperone affecting protein folding. It is known to prevent amyloid generation and accummulation of β-amyloid in vitro. A similar effect of trehalose has been observed with huntingtin protein aggregation. Thus, it might serve as a protective agent in Alzheimer′s disease and Huntington′s disease. |
General description: | Trehalose is a non-reducing disaccharide, ubiquitously present in nature. It is used as a food preservative and also to retain enzymes, vaccines, cells and many other molecules. Trehalose is present as hemolymph sugar among the invertebrates. |
Packaging: | 10, 25, 100 g in poly bottle |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 1 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥99% |
UNSPSC | 12352200 |