Tocainide hydrochloride
SIGMA/T0202 - ≥98% (HPLC), solid
Synonym: 2-
CAS Number: 71395-14-7
Empirical Formula (Hill Notation): C11H16N2O · HCl
Molecular Weight: 228.72
EC Number: 275-361-2
MDL Number: MFCD00941502
Linear Formula: C11H16N2O · HCl
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | white |
| form | solid |
| InChI | 1S/C11H16N2O.ClH/c1-7-5-4 |
| InChI key | AMZACPWEJDQXGW-UHFFFAOYSA |
| originator | AstraZeneca |
| Quality Level | 100  |
| SMILES string | Cl[H].CC(N)C(=O)Nc1c(C)cc |
| solubility | DMSO: >20 mg/mL |
| H2O: ≥5 mg/mL | |
| storage condition | desiccated |
| under inert gas | |
| storage temp. | 2-8°C |
| Application: | Tocainide hydrochloride may be used in cell signaling studies. |
| Biochem/physiol Actions: | Tocainide hydrochloride is a primary amine analog of lidocaine (lignocaine), used for the treatment of tinnitus. It blocks the sodium channels in the pain-producing foci in the nerve membranes and renders an analgesic effect in trigeminal neuralgia. |
| Biochem/physiol Actions: | Tocainide hydrochloride is a sodium channel blocker; Class IB antiarrhythmic. |
| Features and Benefits: | This compound was developed by AstraZeneca . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here . |
| Features and Benefits: | Tocainide is voltage-dependent and use-dependent sodium channel blocker (class IB type antiarrhythmic); Ki = 115 μM in blockade of inactivated-state sodium channels; IC50 = 985μM in blockade of Na+ currents at a holding potential (HP) of -140 mV; IC50 = 254 μM in blockade of Na+ currents at HP -70 mV; IC50 = 523 μM in blockade of Na+ currents at tonic block (-100 mV); IC50 = 248 μM for use-dependent block at 10 Hz. |
| Packaging: | 10, 50 mg in glass bottle |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |