TGFβR2 (190-end), active, GST tagged human
SIGMA/T0203 - PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
Synonym: AAT3; FAA3; HPNCC6; MFS2; RIIC; TAAD2; TGFR-2
Product Type: Chemical
| application(s) | cell analysis |
| assay | ≥70% (SDS-PAGE) |
| biological source | human |
| form | buffered aqueous glycerol solution |
| mol wt | ~68 kDa |
| product line | PRECISIO® Kinase |
| Quality Level | 100  |
| recombinant | expressed in baculovirus infected Sf9 cells |
| shipped in | dry ice |
| specific activity | 6-8 nmol/min·mg |
| storage temp. | −70°C |
| UniProt accession no. | P37173  |
| Biochem/physiol Actions: | Transforming growth factor β receptor 2 (TGFBR2)-induced protein phosphorylation plays a key role in signal transduction that leads to mitogenic responses. The TGFBR2 receptor transmits signals from the cell surface to the nucleus and provides instructions for making transforming growth factor (TGF)-β type II receptor. Mutations in TGFBR2 gene have been associated with Marfan syndrome, Loeys-Deitz aortic aneurysm syndrome and the development of various types of tumors. |
| General description: | Transforming growth factor β receptor 2 (TGFBR2) is a member of the TGFß receptor subfamily and is a serine/threonine protein kinase. The gene encoding this protein is localized on human chromosome 3p24.1. |
| Legal Information: | PRECISIO is a registered trademark of Sigma-Aldrich Co. LLC |
| Physical form: | Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥70% (SDS-PAGE) |
| activity | specific activity: 6-8 nmol/min·mg |
| Storage Temp. | −70°C |
| UNSPSC | 12352200 |