Thiamphenicol

SIGMA/T0261

Synonym: Raceophenidol; Thiophenicol; D-threo-2,2-Dichloro-N-(β-hydroxy-α-[hydroxymethyl]-4-[methylsulfonyl]phenethyl)acetamide

CAS Number: 15318-45-3
Empirical Formula (Hill Notation): C₁₂H₁₅Cl₂NO₅S
Molecular Weight: 356.22
EC Number: 239-355-3
MDL Number: MFCD00467983
Linear Formula: C₁₂H₁₅Cl₂NO₅S
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-T0261-1G	1 g	$70.50 1/EA	Add To Favorites
45-T0261-5G	5 g	$204.00 1/EA	Add To Favorites
45-T0261-25G	25 g	$774.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

antibiotic activity spectrum	Gram-negative bacteria
	Gram-positive bacteria
color	white to off-white
form	powder
InChI	1S/C12H15Cl2NO5S/c1-21(19,20)8-4-2-7(3-5-8)10(17)9(6-16)15-12(18)11(13)14/h2-5,9-11,16-17H,6H2,1H3,(H,15,18)/t9-,10-/m1/s1
InChI key	OTVAEFIXJLOWRX-NXEZZACHSA-N
mode of action	protein synthesis \| interferes
Quality Level	100
SMILES string	CS(=O)(=O)c1ccc(cc1)[C@@H](O)[C@@H](CO)NC(=O)C(Cl)Cl
solubility	ethanol: soluble 50 mg/mL

Application:	Thiamphenicol is an antibiotic that has been used to treat chancroid in men and uncomplicated gonorrhea. It is used in studies of bacterial protein synthesis at the level of peptidyl transferase activity associated with the 23S rRNA of the 50S ribosomal subunit. It is used to study chloraniphenicol-thiamphenicol-resistance and the use of fluorinated analogs when resistance is encountered.
Biochem/physiol Actions:	Thiamphenicol inhibits mitochondrial protein synthesis of proteins such as cytochrome c oxidase.
General description:	Chemical structure: phenicole
Other Notes:	Keep container tightly closed in a dry and well-ventilated place.
Packaging:	1G,5G,25G

RIDADR	NONH for all modes of transport
WGK Germany	WGK 2
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

UNSPSC

51101500

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