Tolfenamic acid
SIGMA/T0535 - NSAID
Synonym: 2 (3-
CAS Number: 13710-19-5
Empirical Formula (Hill Notation): C14H12ClNO2
Molecular Weight: 261.70
EC Number: 237-264-3
MDL Number: MFCD00133865
Linear Formula: C14H12ClNO2
Product Type: Chemical
assay | ≥98% (TLC) |
form | powder |
InChI | 1S/C14H12ClNO2/c1-9-11(15 |
InChI key | YEZNLOUZAIOMLT-UHFFFAOYSA |
Quality Level | 200 |
SMILES string | Cc1c(Cl)cccc1Nc2ccccc2C(O |
solubility | ethanol: 50 mg/mL, clear, greenish-yellow |
Application: | Tolfenamic acid has been used in Arabidopsis bud assay for activity comparison with quinazolinedione derivatives (QADD) based compounds. |
Biochem/physiol Actions: | Non-steroidal anti-inflammatory agent. Interferes with synthesis of β-amyloid precursor protein, and thus Aβ peptides, by promoting degradation of an essential transcription factor. |
Biochem/physiol Actions: | Tolfenamic acid is involved in the inhibition of prostaglandin synthesis. It also plays a role in apoptosis of head and neck cancer cells. |
General description: | Tolfenamic acid is a fenamate and is made up of a monocarboxylate diphenylamine nucleus. |
Packaging: | 5 g in glass bottle |
Symbol | GHS06 |
Signal word | Danger |
Hazard statements | H301 |
Precautionary statements | P301 + P310 |
Hazard Codes | Xn |
Risk Statements | 22 |
RIDADR | UN 2811 6.1 / PGIII |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (TLC) |
UNSPSC | 12352202 |