Tau-441 human
SIGMA/T0576 - recombinant, expressed in E. coli, ≥90% (SDS-PAGE), lyophilized powder
MDL Number: MFCD07785735
Product Type: Chemical
| application(s) | cell analysis |
| assay | ≥90% (SDS-PAGE) |
| biological source | human |
| form | lyophilized powder |
| mol wt | 45.9 kDa |
| Quality Level | 200  |
| recombinant | expressed in E. coli |
| shipped in | wet ice |
| storage temp. | −20°C |
| UniProt accession no. | P10636  |
| Application: | Human Tau-441 has been used to study the effects of tau on neuropathological changes in Alzheimer′s disease. |
| Application: | Tau-441 human has been used to study its effects on mitochondrial transport velocities found in glial cells. |
| Biochem/physiol Actions: | Isoform of Tau, variant 2N4R, having 4 microtubule binding repeats (R) and 2 amino terminal inserts (N) |
| Biochem/physiol Actions: | Microtubule associated protein tau (MAPT) plays an important role in the assembly and maintenance of the microtubule structure. Loss of expression of MAPT results in developmental delay and learning disability. The protein has been associated with pathology of Alzheimer′s disease (AD). |
| Biochem/physiol Actions: | Tau promotes assembly and stabilizes neuronal microtubules under normal physiological conditions. |
| General description: | Tau-441 human, recombinant, is an isoform of Tau, variant 2N4R, having 4 microtubule binding repeats (R) and 2 amino terminal inserts (N). Tau is a family of neuronal microtubule-associated proteins. Tau, a phosphoprotein is considered as an important microtubule associated protein (MAP) of a mature neuron. The 2N4R tau consists of 441 amino acids (tau441) and is considered as the largest size human brain tau. In human brain, tau is present in six molecular isoforms. |
| General description: | The gene microtubule associated protein tau (MAPT) is localized on human chromosome 17q21.3. It is expressed in neurons, more specifically in axons. |
| Reconstitution: | Lyophilized from MES, pH 6.8, containing NaCl and EGTA. When reconstituted in water to a protein concentration of 1 mg/mL, the resulting buffer will have ~50 mM MES, pH 6.8, 100 mM NaCl, and 0.5 mM EGTA. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥90% (SDS-PAGE) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |