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Trimethoprim lactate salt

SIGMA/T0667 - ≥98%

Synonym: 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate; 2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine lactate salt

CAS Number: 23256-42-0
Empirical Formula (Hill Notation): C14H18N4O3 · C3H6O3
Molecular Weight: 380.40
EC Number: 245-533-1
MDL Number: MFCD00171722
Linear Formula: C14H18N4O3 · C3H6O3
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-T0667-250MG 250 mg
 $382.00
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This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: T0667-250MG

 

antibiotic activity spectrum Gram-negative bacteria
  Gram-positive bacteria
  mycobacteria
assay ≥98%
color white
form powder
InChI 1S/C14H18N4O3.C3H6O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15;1-2(4)3(5)6/h5-7H,4H2,1-3H3,(H4,15,16,17,18);2,4H,1H3,(H,5,6)
InChI key IIZVTUWSIKTFKO-UHFFFAOYSA-N
mode of action DNA synthesis | interferes
  enzyme | inhibits
Quality Level 200 
SMILES string CC(O)C(O)=O.COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC
solubility H2O: soluble 20 mg/mL
storage condition (Keep container tightly closed in a dry and well-ventilated place.)
storage temp. 2-8°C
Application: Trimethoprim is primarily used as an antibacterial agent. It has dihydrofolate reductase inhibitor activity with selectivity for the prokaryote enzyme. It is used clinically to treat urinary tract infections, mild acute prostatitis, recurrent cystitis, asymptomatic bacteriuria during pregnancy and respiratory tract infections. Trimethoprim lactate salt is used as a selection agent.
Biochem/physiol Actions: The combination of trimethoprim and sulfamethoxazole interferes with the cellular metabolism of folic acid in the bacterial cell by blocking the biosynthesis of nucleotides. Trimethoprim binds to prokaryote-specific dihydrofolate reductase (DHFR) and inhibits the reduction of dihydrofolic acid (DHF) to tetrahydrofolic acid (THF). THF is an essential precursor in the thymidine synthesis pathway and interference with this pathway inhibits bacterial DNA synthesis.
General description: Chemical structure: pyrimidine
Other Notes: Keep container tightly closed in a dry and well-ventilated place.
Packaging: 250 mg in glass bottle
Purity ≥98%
Storage Temp. 2-8°C
UNSPSC 51285203

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