Synonym: 4,5,6,7-Tetrabromo-2-azabenzimidazole; 4,5,6,7-Tetrabromobenzotriazole; NSC 231634; TBBt
CAS Number: 17374-26-4
Empirical Formula (Hill Notation): C6HN3Br4
Molecular Weight: 434.71
MDL Number: MFCD06411399
Linear Formula: C6HN3Br4
Product Type: Chemical
assay |
≥98% (HPLC) |
color |
white |
form |
solid |
InChI |
1S/C6HBr4N3/c7-1-2(8)4(10)6-5(3(1)9)11-13-12-6/h(H,11,12,13) |
InChI key |
OMZYUVOATZSGJY-UHFFFAOYSA-N |
Quality Level |
100 ![External link](https://krackeler.com/images/sigma/ext-link.gif) |
SMILES string |
Brc1c(Br)c(Br)c2[nH]nnc2c1Br |
solubility |
DMSO: 28 mg/mL |
storage temp. |
2-8°C |
Application: |
TBB was used to study casein kinase 2-dependent phosphorylation of DNA damage mediator protein MDC1. |
Biochem/physiol Actions: |
TBB binds to the Val66 residue of casein kinase-2 and inhibits the binding of ATP/GTP. TBB is cell permeable; it induces caspase-dependent apoptosis and degrades hematopoietic lineage cell-specific protein 1 in Jurkat cells. |
Biochem/physiol Actions: |
TBB is a highly selective, ATP/GTP-competitive inhibitor of casein kinase-2 (CK2) (IC50 = 900 nM and 1.6 mM, using rat liver and recombinant human CK2, respectively). |
Packaging: |
10 mg in glass bottle |
RIDADR |
NONH for all modes of transport |
WGK Germany |
WGK 3 |
Purity |
≥98% (HPLC) |
Storage Temp. |
2-8°C |
UNSPSC |
12352200 |