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TBB

SIGMA/T0826 - ≥98% (HPLC), solid

Synonym: 4,5,6,7-Tetrabromo-2-azabenzimidazole; 4,5,6,7-Tetrabromobenzotriazole; NSC 231634; TBBt

CAS Number: 17374-26-4
Empirical Formula (Hill Notation): C6HN3Br4
Molecular Weight: 434.71
MDL Number: MFCD06411399
Linear Formula: C6HN3Br4
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-T0826-10MG 10 mg
 $311.00
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assay ≥98% (HPLC)
color white
form solid
InChI 1S/C6HBr4N3/c7-1-2(8)4(10)6-5(3(1)9)11-13-12-6/h(H,11,12,13)
InChI key OMZYUVOATZSGJY-UHFFFAOYSA-N
Quality Level 100 
SMILES string Brc1c(Br)c(Br)c2[nH]nnc2c1Br
solubility DMSO: 28 mg/mL
storage temp. 2-8°C
Application: TBB was used to study casein kinase 2-dependent phosphorylation of DNA damage mediator protein MDC1.
Biochem/physiol Actions: TBB binds to the Val66 residue of casein kinase-2 and inhibits the binding of ATP/GTP. TBB is cell permeable; it induces caspase-dependent apoptosis and degrades hematopoietic lineage cell-specific protein 1 in Jurkat cells.
Biochem/physiol Actions: TBB is a highly selective, ATP/GTP-competitive inhibitor of casein kinase-2 (CK2) (IC50 = 900 nM and 1.6 mM, using rat liver and recombinant human CK2, respectively).
Packaging: 10 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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