Thyroglobulin from bovine thyroid
SIGMA/T1001 - powder, ≥90% (agarose gel electrophoresis)
Synonym: Globulins thyro; Thyractin
CAS Number: 9010-34-8
EC Number: 232-721-3
MDL Number: MFCD00132429
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: T1001-5G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: T1001-100MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: T1001-1G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: T1001-500MG
| ash | ≤4% |
| assay | ≥90% (agarose gel electrophoresis) |
| biological source | bovine thyroid |
| composition | Iodine, ≥0.20% |
| form | powder |
| mol wt | ~670 kDa |
| nitrogen analysis | 13.0-16.0% total |
| Quality Level | 200  |
| solubility | H2O: 20 mg/mL |
| storage temp. | −20°C |
| UniProt accession no. | P01267  |
| Application: | Bovine thyroglobulin was shown to stimulate proliferation in rat thyroid follicular cells as well as in primary porcine thyroid epithelial cells. This effect was mediated through PI3K signaling. |
| Application: | Often used as a carrier protein for the production of antibodies. Its advantage is the large number of tyrosine residues that can be used for conjugation using the diazo reaction. |
| Biochem/physiol Actions: | Bovine thyroglobulin is a large, tetrameric glycoprotein produced in the thyroid gland as a precursor to thyroid hormones. Its large size and absence from plasma under normal conditions makes it very immunogenic and reduces the chance that antibodies to this carrier protein will cross-react with plasma proteins in immunoassays. Haptens may be conjugated to thyroglobulin via accessible secondary amines. |
| Biochem/physiol Actions: | Iodine-containing protein that is stored in the thyroid gland. Converted into circulating thyroxines when the thyroid is stimulated by thyroid-stimulating hormone (TSH) from the pituitary. Because its expression is unique to the thyroid, it is a sensitive indicator of recurrence or metastasis of thyroid cancer that has been treated by thyroid ablation. |
| Packaging: | 1, 5 g in poly bottle |
| Packaging: | 100, 500 mg in poly bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥90% (agarose gel electrophoresis) |
| Storage Temp. | −20°C |
| UNSPSC | 12352202 |