Thyroglobulin from bovine thyroid
SIGMA/T1001 - powder, ≥90% (agarose gel electrophoresis)
Synonym: Globulins thyro; Thyractin
CAS Number: 9010-34-8
EC Number: 232-721-3
MDL Number: MFCD00132429
Product Type: Chemical
ash | ≤4% |
assay | ≥90% (agarose gel electrophoresis) |
biological source | bovine thyroid |
composition | Iodine, ≥0.20% |
form | powder |
mol wt | ~670 kDa |
nitrogen analysis | 13.0-16.0% total |
Quality Level | 200 ![]() |
solubility | H2O: 20 mg/mL |
storage temp. | −20°C |
UniProt accession no. | P01267 ![]() ![]() |
Application: | Bovine thyroglobulin was shown to stimulate proliferation in rat thyroid follicular cells as well as in primary porcine thyroid epithelial cells. This effect was mediated through PI3K signaling. |
Application: | Often used as a carrier protein for the production of antibodies. Its advantage is the large number of tyrosine residues that can be used for conjugation using the diazo reaction. |
Biochem/physiol Actions: | Bovine thyroglobulin is a large, tetrameric glycoprotein produced in the thyroid gland as a precursor to thyroid hormones. Its large size and absence from plasma under normal conditions makes it very immunogenic and reduces the chance that antibodies to this carrier protein will cross-react with plasma proteins in immunoassays. Haptens may be conjugated to thyroglobulin via accessible secondary amines. |
Biochem/physiol Actions: | Iodine-containing protein that is stored in the thyroid gland. Converted into circulating thyroxines when the thyroid is stimulated by thyroid-stimulating hormone (TSH) from the pituitary. Because its expression is unique to the thyroid, it is a sensitive indicator of recurrence or metastasis of thyroid cancer that has been treated by thyroid ablation. |
Packaging: | 1, 5 g in poly bottle |
Packaging: | 100, 500 mg in poly bottle |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥90% (agarose gel electrophoresis) |
Storage Temp. | −20°C |
UNSPSC | 12352202 |