DMT-dT Pharmadite®
SIGMA/T11100P
Synonym: 5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxythymidine, 3′-[2-cyanoethyl N,N-
CAS Number: 98796-51-1
Empirical Formula (Hill Notation): C40H49N4O8P
Molecular Weight: 744.81
MDL Number: MFCD00055063
Linear Formula: C40H49N4O8P
Product Type: Chemical
| assay | ≥99.5% (reversed phase HPLC) |
| >99.5% (31P-NMR) | |
| biological source | non-animal source (no BSE/TSE risk) |
| color | white to off-white |
| form | powder or granules |
| impurities | >= 170ppm, none detected (S/N <2.5) |
| ≤0.1% P(III) 100-169ppm (31P-NMR) | |
| ≤0.1% single unspecified Imprity (reversed phase HPLC) | |
| ≤0.3% dT2 (reversed phase HPLC, DMT-dT cyanoethyl-H-posphonate) | |
| ≤0.3% dT3 (reversed phase HPLC, DMT-dT phosphoramidate) | |
| ≤0.30 wt. % water content (Karl Fischer) | |
| ≤0.5% P(V) -25-99ppm (31P-NMR) | |
| ≤3.0 wt. % residual solvent content | |
| InChI | 1S/C40H49N4O8P/c1-27(2)44 |
| InChI key | UNOTXUFIWPRZJX-CEXSRUIHSA |
| nucleoside profile | base: deoxythymidine base protecting group: none 2' protecting group: none 5' protecting group: DMT deprotection: standard |
| product line | Proligo Reagents |
| Quality Level | 300  |
| SMILES string | COc1ccc(cc1)C(OC[C@H]2O[C |
| solubility | soluble, clear |
| storage temp. | 2-8°C |
| suitability | conforms to structure for H-NMR |
| conforms to structure for LC-MS | |
| technique(s) | oligo synthesis: suitable |
| type | for DNA synthesis |
| General description: | DMT-dT Pharmadite® is a Pharmadite® product line that represents a new class of standard protected DNA phosphoramidites designed with highly controlled impurity profiles and exceptional overall purity.Pharmadite phosphoramidites are characterized by their exceptional purity and well-defined impurity profile. In particular, they are essentially free fromcontaminants that interfere in coupling reactions, such as other nucleosidic or non-nucleosidic phosphoramidites (P(III)-contaminants). All remainingimpurities in Pharmadite phosphopramidites, if present, are identified, characterized, and quantified. The impact of any such defined impurities on the synthesis of oligonucleotides is well understood and has been shown to be insignificant. |
| Legal Information: | Pharmadite is a registered trademark of Sigma-Aldrich Co. LLC |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥99.5% (reversed phase HPLC); >99.5% (31P-NMR) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |