holo-Transferrin bovine
SIGMA/T1408
Synonym: Siderophilin; Siderophilin, iron-saturated
CAS Number: 11096-37-0
EC Number: 234-318-8
MDL Number: MFCD00131337
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: T1408-1G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: T1408-500MG
| assay | 97-100% (agarose gel electrophoresis) |
| biological source | bovine |
| form | powder |
| Quality Level | 200  |
| storage temp. | 2-8°C |
| technique(s) | cell culture | mammalian: suitable |
| UniProt accession no. | Q29443  |
| Analysis Note: | Purity by agarose gel electrophoresis. |
| Application: | Holo-Transferrin bovine has been used: • as a RPMI-1640 medium supplement for culturing cancer cell lines • as a component of visceral fat differentiation medium for the pre-adipocytes primary cell culture • to test the influence of iron-saturation complex on the growth of Malassezia pachydermatis • as a standard for strong anion exchange (SAX) reactor measurements |
| Biochem/physiol Actions: | Holo-Transferrin (holo-Tf) or the iron bound transferrin functions as an iron sequester and is crucial for defense against microbial infections. Transferrin is used as a model system for understanding the kinetics and dynamics of protein structure based interactions. It is a potential candidate for delivery studies for its ability to cross the blood-brain barrier. The interaction of holo-Tf with thrombin is implicated in the pathogenesis of intracerebral hemorrhage. Polymorphisms in the bovine transferrin gene has led to the generation of 10 variant transferrin protein. |
| Biochem/physiol Actions: | Studies show that treatment of breast cancer cells with holo-transferrin in combination with dihydroartemisinin results in increased tumor cell death due to elevated levels of intracellular ferrous iron. |
| General description: | Holo-Transferrin is an iron transporting glycoprotein and belongs to metalloprotein class. The gene encoding transferrin is mapped to bovine chromosome 1. |
| Packaging: | 1 g in poly bottle |
| Packaging: | 50, 500 mg in poly bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | 97-100% (agarose gel electrophoresis) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352202 |