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(±)-Thalidomide

SIGMA/T144 - ≥98%, powder

Synonym: (±)-2-(2,6-Dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione

CAS Number: 50-35-1
Empirical Formula (Hill Notation): C13H10N2O4
Molecular Weight: 258.23
EC Number: 200-031-1
MDL Number: MFCD00153873
Linear Formula: C13H10N2O4
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-T144-100MG 100 mg
 $95.90
1/EA		 Add To Favorites
45-T144-1G 1 g
 $760.00
1/EA		 Add To Favorites
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: T144-100MG.
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: T144-1G

 

assay ≥98%
color white
form powder
InChI 1S/C13H10N2O4/c16-10-6-5-9(11(17)14-10)15-12(18)7-3-1-2-4-8(7)13(15)19/h1-4,9H,5-6H2,(H,14,16,17)
InChI key UEJJHQNACJXSKW-UHFFFAOYSA-N
ligand thalidomide
originator Celgene
Quality Level 200 
reaction suitability reagent type: ligand
SMILES string O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1
solubility DMSO: 20 mg/mL, clear
Application: Thalidomide has been used to study its neuropathological effects in mouse models of Alzheimer′s disease (AD). This study reported that long term administration of thalidomide causes beta-secretase inhibition and subsequently alleviates amyloid-like pathology. Furthermore, thalidomide has also been used to evaluate its teratogenic functions. Thalidomide was found to affect endodermal differentiation and neural development in differentiating human embryonic and induced pluripotent stem cells.
Biochem/physiol Actions: (±)-Thalidomide selectively inhibits biosynthesis of tumor necrosis factor α (TNF-α). It also functions as an inhibitor of angiogenesis, an immunosuppressive agent, a sedative and a teratogen. Furthermore, thalidomide is known to exhibit antitumor functions in refractory multiple myeloma.
Features and Benefits: This compound was developed by Celgene . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging: 1 g in glass bottle
Packaging: 100 mg in glass bottle
Preparation Note: Thalidomide is soluble in DMSO at a concentration that is more than 20 mg/ml. It is insoluble in water and ethanol.
Purity ≥98%
UNSPSC 12352111

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