Synonym: 1,4-Bis-[2-(3,5-dichloropyridyloxy)]benzene; 3,3′,5,5′-Tetrachloro-1,4-bis(pyridyloxy)benzene
CAS Number: 76150-91-9
Empirical Formula (Hill Notation): C16H8N2O2Cl4
Molecular Weight: 402.06
MDL Number: MFCD00057368
Linear Formula: C16H8N2O2Cl4
Product Type: Chemical
| assay |
≥98% (HPLC) |
| color |
white |
| form |
solid |
| InChI |
1S/C16H8Cl4N2O2/c17-9-5-13(19)15(21-7-9)23-11-1-2-12(4-3-11)24-16-14(20)6-10(18)8-22-16/h1-8H |
| InChI key |
BAFKRPOFIYPKBQ-UHFFFAOYSA-N |
| Quality Level |
100  |
| SMILES string |
Clc1cnc(Oc2ccc(Oc3ncc(Cl)cc3Cl)cc2)c(Cl)c1 |
| solubility |
DMSO: >10 mg/mL |
| |
H2O: insoluble |
| storage temp. |
2-8°C |
| Application: |
TCPOBOP has been used for enhancing Mcl-1-Italics promoter functions in mouse hepatoma cells. TCPOBOP has also been used to study constitutive androstane receptor(CAR)-induced gene expression in mouse hepatocytes. |
| Biochem/physiol Actions: |
TCPOBOP enhances the nuclear receptor CAR transactivation of cytochrome P450 (CYP), as dose-dependent direct agonist of CAR. The most potent known member of the phenobarbital-like class of CYP-inducing agents. |
| Features and Benefits: |
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| Packaging: |
5 mg in glass bottle |
| Preparation Note: |
TCPOBOP is soluble in DMSO at a concentration that is greater than 10 mg/ml. It is insoluble in water. |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥98% (HPLC) |
| Storage Temp. |
2-8°C |
| UNSPSC |
12352200 |
