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TPCA-1

SIGMA/T1452 - ≥95% (HPLC)

Synonym: [5-(p-Fluorophenyl)-2-ureido]thiophene-3-carboxamide

CAS Number: 507475-17-4
Empirical Formula (Hill Notation): C12H10FN3O2S
Molecular Weight: 279.29
MDL Number: MFCD09037541
Linear Formula: C12H10FN3O2S
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-T1452-1MG 1 mg
 $179.00
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45-T1452-5MG 5 mg
 $717.00
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assay ≥95% (HPLC)
color white to light brown
form powder
InChI 1S/C12H10FN3O2S/c13-7-3-1-6(2-4-7)9-5-8(10(14)17)11(19-9)16-12(15)18/h1-5H,(H2,14,17)(H3,15,16,18)
InChI key SAYGKHKXGCPTLX-UHFFFAOYSA-N
originator GlaxoSmithKline
Quality Level 100 
SMILES string NC(=O)Nc1sc(cc1C(N)=O)-c2ccc(F)cc2
solubility DMSO: 5 mg/mL, clear
storage temp. 2-8°C
Application: TPCA-1 has been used to study its cytotoxic effects in RPMI8226 and LP1 cell lines. It has also been used as a culture media supplement for nuclear protein fractions extracted from human airway smooth muscle cells.
Biochem/physiol Actions: IKK-2 Inhibitor
Biochem/physiol Actions: TPCA-1 is a potent and selective inhibitor of human IκB kinase-2 (IKK-2) with IC50 = 17.9 nM for IKK-2 compared to 400nm for IKK-1. It has been used to study inhibition of IKK-2 to prevent inflammatory mediator release in animal models of arthritis and airway inflammation.
Features and Benefits: This compound was developed by GlaxoSmithKline . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging: 1, 5 mg in glass bottle
Preparation Note: TPCA-1 is soluble in DMSO at a concentration that is greater than or equal to 10 mg/ml. It is insoluble in water.
Hazard Codes Xn
Risk Statements 22-36
Safety Statements 26
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Purity ≥95% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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