TPCA-1
SIGMA/T1452 - ≥95% (HPLC)
Synonym: [5-
CAS Number: 507475-17-4
Empirical Formula (Hill Notation): C12H10FN3O2S
Molecular Weight: 279.29
MDL Number: MFCD09037541
Linear Formula: C12H10FN3O2S
Product Type: Chemical
assay | ≥95% (HPLC) |
color | white to light brown |
form | powder |
InChI | 1S/C12H10FN3O2S/c13-7-3-1 |
InChI key | SAYGKHKXGCPTLX-UHFFFAOYSA |
originator | GlaxoSmithKline |
Quality Level | 100 ![]() |
SMILES string | NC(=O)Nc1sc(cc1C(N)=O)-c2 |
solubility | DMSO: 5 mg/mL, clear |
storage temp. | 2-8°C |
Application: | TPCA-1 has been used to study its cytotoxic effects in RPMI8226 and LP1 cell lines. It has also been used as a culture media supplement for nuclear protein fractions extracted from human airway smooth muscle cells. |
Biochem/physiol Actions: | TPCA-1 is a potent and selective inhibitor of human IκB kinase-2 (IKK-2) with IC50 = 17.9 nM for IKK-2 compared to 400nm for IKK-1. It has been used to study inhibition of IKK-2 to prevent inflammatory mediator release in animal models of arthritis and airway inflammation. |
Features and Benefits: | This compound was developed by GlaxoSmithKline ![]() ![]() |
Packaging: | 1, 5 mg in glass bottle |
Preparation Note: | TPCA-1 is soluble in DMSO at a concentration that is greater than or equal to 10 mg/ml. It is insoluble in water. |
Hazard Codes | Xn |
Risk Statements | 22-36 |
Safety Statements | 26 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Purity | ≥95% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |