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TNP-470

SIGMA/T1455 - ≥98% (HPLC)

Synonym: (Chloracetyl) carbamic acid (3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5]oct-6-yl ester; AGM-1470; NSC 642492; O-Chloracetyl-carbamoyl fumagillol

CAS Number: 129298-91-5
Empirical Formula (Hill Notation): C19H28ClNO6
Molecular Weight: 401.88
MDL Number: MFCD00870281
Linear Formula: C19H28ClNO6
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-T1455-5MG 5 mg
 $258.00
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45-T1455-25MG 25 mg
 $996.00
1/EA		 Add To Favorites
This picture is provided solely for illustration purposes, it may have been created or edited with AI. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.
This image depicts T1455-25MG.

 

assay ≥98% (HPLC)
form solid
InChI 1S/C19H28ClNO6/c1-11(2)5-6-13-18(3,27-13)16-15(24-4)12(7-8-19(16)10-25-19)26-17(23)21-14(22)9-20/h5,12-13,15-16H,6-10H2,1-4H3,(H,21,22,23)/t12-,13-,15-,16-,18+,19+/m1/s1
InChI key MSHZHSPISPJWHW-PVDLLORBSA-N
originator Takeda
Quality Level 100 
SMILES string CO[C@@H]1[C@@H](CC[C@]2(CO2)C1[C@@]3(C)O[C@@H]3CC=C(C)C)OC(=O)NC(=O)CCl
solubility DMSO: >15 mg/mL
storage temp. −20°C
Biochem/physiol Actions: Studies have reported that TNP-470 can decrease intimal neovascularization in Apo-E deficient mice. TNP-470 can also prevent tumor growth in human breast and prostate cancer cell lines.
Biochem/physiol Actions: TNP-470 is a methionine aminopeptidase-2 (MetAP-2) inhibitor, selective for MetAP-2 over MetAP11. TNP-470 is an antiangiogenic.
Biochem/physiol Actions: TNP-470 is a methionine aminopeptidase-2 (MetAP-2) inhibitor.
Features and Benefits: This compound was developed by Takeda . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
General description: TNP-470 is a synthetic analogue of fumagillin. It is a natural product of Aspergillus fumigatus. TNP-470 serves as an angiogenesis inhibitor.
Other Notes: TNP-470 is hygroscopic.
Packaging: 5, 25 mg in glass bottle
Preparation Note: TNP-470 is soluble in DMSO at a concentration that is greater than 15 mg/ml.
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26
RIDADR NONH for all modes of transport
WGK Germany WGK 2
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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