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TNP-470

SIGMA/T1455 - ≥98% (HPLC)

Synonym: (Chloracetyl) carbamic acid (3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5]oct-6-yl ester; AGM-1470; NSC 642492; O-Chloracetyl-carbamoyl fumagillol

CAS Number: 129298-91-5
Empirical Formula (Hill Notation): C19H28ClNO6
Molecular Weight: 401.88
MDL Number: MFCD00870281
Linear Formula: C19H28ClNO6
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-T1455-5MG 5 mg
 $240.00
1/EA		 Add To Favorites
45-T1455-25MG 25 mg
 $929.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
form solid
InChI 1S/C19H28ClNO6/c1-11(2)5-6-13-18(3,27-13)16-15(24-4)12(7-8-19(16)10-25-19)26-17(23)21-14(22)9-20/h5,12-13,15-16H,6-10H2,1-4H3,(H,21,22,23)/t12-,13-,15-,16-,18+,19+/m1/s1
InChI key MSHZHSPISPJWHW-PVDLLORBSA-N
originator Takeda
Quality Level 100 
SMILES string CO[C@@H]1[C@@H](CC[C@]2(CO2)C1[C@@]3(C)O[C@@H]3CC=C(C)C)OC(=O)NC(=O)CCl
solubility DMSO: >15 mg/mL
storage temp. −20°C
Biochem/physiol Actions: Studies have reported that TNP-470 can decrease intimal neovascularization in Apo-E deficient mice. TNP-470 can also prevent tumor growth in human breast and prostate cancer cell lines.
Biochem/physiol Actions: TNP-470 is a methionine aminopeptidase-2 (MetAP-2) inhibitor, selective for MetAP-2 over MetAP11. TNP-470 is an antiangiogenic.
Biochem/physiol Actions: TNP-470 is a methionine aminopeptidase-2 (MetAP-2) inhibitor.
Features and Benefits: This compound was developed by Takeda . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
General description: TNP-470 is a synthetic analogue of fumagillin. It is a natural product of Aspergillus fumigatus. TNP-470 serves as an angiogenesis inhibitor.
Other Notes: TNP-470 is hygroscopic.
Packaging: 5, 25 mg in glass bottle
Preparation Note: TNP-470 is soluble in DMSO at a concentration that is greater than 15 mg/ml.
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26
RIDADR NONH for all modes of transport
WGK Germany WGK 2
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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