(+)-Thalidomide

SIGMA/T151 - ≥98% (HPLC), powder

Synonym: R-(+)-2-(2,6-Dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione

CAS Number: 2614-06-4
Empirical Formula (Hill Notation): C₁₃H₁₀N₂O₄
Molecular Weight: 258.23
MDL Number: MFCD00210220
Linear Formula: C₁₃H₁₀N₂O₄
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-T151-10MG	10 mg	$142.00 1/EA		Add To Favorites
45-T151-100MG	100 mg	$910.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C13H10N2O4/c16-10-6-5-9(11(17)14-10)15-12(18)7-3-1-2-4-8(7)13(15)19/h1-4,9H,5-6H2,(H,14,16,17)/t9-/m1/s1
InChI key	UEJJHQNACJXSKW-SECBINFHSA-N
ligand	thalidomide
originator	Celgene
Quality Level	200
reaction suitability	reagent type: ligand
SMILES string	O=C1CC[C@@H](N2C(=O)c3ccccc3C2=O)C(=O)N1
solubility	DMSO: 15 mg/mL, clear
storage temp.	room temp

Application:	Thalidomide has been used to study its teratogenic effects in chicken embryos and human embryonic cells. This study reported that thalidomide causes limb defects by stabilizing PTEN, inhibiting the expression of Akt and activating caspase-dependent apoptosis. Thalidomide has also been used for studying glutathione mediated teratogenic resistance in mouse embryos.
Biochem/physiol Actions:	(-)-Thalidomide selectively inhibits biosynthesis of tumor necrosis factor α (TNF-α). (R)-Thalidomide is called "safe enantiomer", but it can be converted in the body to (S)-isomer.
Features and Benefits:	This compound was developed by Celgene . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging:	10, 100 mg in glass bottle
Preparation Note:	Thalidomide is soluble in DMSO at a concentration that is greater than or equal to 20 mg/ml. It is insoluble in ethanol and water.

Symbol	GHS07,GHS08
Signal word	Danger
Hazard statements	H302 - H360
Precautionary statements	P201 - P301 + P312 + P330 - P308 + P313
Hazard Codes	T
Risk Statements	61-22
Safety Statements	53-36/37/39-45
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	room temp
UNSPSC	12352200

Choose a favorite list for this item:

Catalog Number	Description	Price

		$

Please choose a list :

Continue Shopping

Returns/Order support

Please fill out the form below if you want to request order support from Krackeler Scientific.