Thrombin Receptor Activator Peptide 6
SIGMA/T1573 - >95% (HPLC)
Synonym: TRAP-6
CAS Number: 141136-83-6
Empirical Formula (Hill Notation): C34H56N10O9
Molecular Weight: 748.87
MDL Number: MFCD00238172
Linear Formula: C34H56N10O9
Product Type: Chemical
assay | >95% (HPLC) |
form | lyophilized |
InChI | 1S/C34H56N10O9/c1-18(2)13 |
InChI key | HAGOWCONESKMDW-FRSCJGFNSA |
Quality Level | 200 ![]() |
SMILES string | CC(C)C[C@H](NC(=O)[C@H](C |
solubility | 0.1% TFA: soluble |
water: soluble | |
storage temp. | −20°C |
technique(s) | cell culture | mammalian: suitable |
UniProt accession no. | P25116 ![]() ![]() |
Amino Acid Sequence: | Ser-Phe-Leu-Leu-Arg-Asn |
Application: | Thrombin Receptor Activator Peptide 6 has been used to activate platelets in vitro. It has also been used to downregulate hippo signaling and increase nuclear yes-associated protein (YAP). |
Biochem/physiol Actions: | Hexapeptide fragment of the thrombin receptor (residues 42-47). Shown to activate the thrombin receptor and cause platelet aggregation (EC50 = 0.8 μM). |
General description: | Thrombin Receptor Activator Peptide 6 (TRAP-6) protects astrocytes from cell death, which is associated with hypoglycemia. TRAP-6 induced aggregation and impaired adhesion to collagen under flow conditions. |
Other Notes: | Lyophilized from 0.1% TFA in H2O |
Packaging: | 5 mg in glass bottle |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | >95% (HPLC) |
Storage Temp. | −20°C |
UNSPSC | 12352200 |