Thrombin Receptor Activator Peptide 6

SIGMA/T1573 - >95% (HPLC)

Synonym: TRAP-6

CAS Number: 141136-83-6
Empirical Formula (Hill Notation): C₃₄H₅₆N₁₀O₉
Molecular Weight: 748.87
MDL Number: MFCD00238172
Linear Formula: C₃₄H₅₆N₁₀O₉
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-T1573-5MG	5 mg	$490.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	>95% (HPLC)
form	lyophilized
InChI	1S/C34H56N10O9/c1-18(2)13-23(30(49)40-22(11-8-12-39-34(37)38)29(48)44-26(33(52)53)16-27(36)46)42-31(50)24(14-19(3)4)43-32(51)25(41-28(47)21(35)17-45)15-20-9-6-5-7-10-20/h5-7,9-10,18-19,21-26,45H,8,11-17,35H2,1-4H3,(H2,36,46)(H,40,49)(H,41,47)(H,42,50)(H,43,51)(H,44,48)(H,52,53)(H4,37,38,39)/t21-,22-,23-,24-,25-,26-/m0/s1
InChI key	HAGOWCONESKMDW-FRSCJGFNSA-N
Quality Level	200
SMILES string	CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(O)=O
solubility	0.1% TFA: soluble
	water: soluble
storage temp.	−20°C
technique(s)	cell culture \| mammalian: suitable
UniProt accession no.	P25116

Amino Acid Sequence:	Ser-Phe-Leu-Leu-Arg-Asn
Application:	Thrombin Receptor Activator Peptide 6 has been used to activate platelets in vitro. It has also been used to downregulate hippo signaling and increase nuclear yes-associated protein (YAP).
Biochem/physiol Actions:	Hexapeptide fragment of the thrombin receptor (residues 42-47).
Biochem/physiol Actions:	Hexapeptide fragment of the thrombin receptor (residues 42-47). Shown to activate the thrombin receptor and cause platelet aggregation (EC₅₀ = 0.8 μM).
General description:	Thrombin Receptor Activator Peptide 6 (TRAP-6) protects astrocytes from cell death, which is associated with hypoglycemia. TRAP-6 induced aggregation and impaired adhesion to collagen under flow conditions.
Other Notes:	Lyophilized from 0.1% TFA in H2O
Packaging:	5 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	>95% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352200

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