Synonym: 7-[(3-Chloro-6,11-dihydro-6-methyl-dibenzo[c,f][1,2]thiazepine-11-yl)amino]heptanoic acid S,S dioxide sodium salt hydrate
CAS Number: 30123-17-2 (anhydrous)
Empirical Formula (Hill Notation): C21H24ClN2NaO4S · xH2O
Molecular Weight: 458.93 (anhydrous basis)
Linear Formula: C21H24ClN2NaO4S · xH2O
Product Type: Chemical
| assay |
≥98% (HPLC) |
| color |
white to tan |
| form |
powder |
| InChI |
1S/C21H25ClN2O4S.Na.H2O/c1-24-18-9-6-5-8-16(18)21(23-13-7-3-2-4-10-20(25)26)17-12-11-15(22)14-19(17)29(24,27)28;;/h5-6,8-9,11-12,14,21,23H,2-4,7,10,13H2,1H3,(H,25,26);;1H2/q;+1;/p-1 |
| InChI key |
HNTRDGDHBBFLPG-UHFFFAOYSA-M |
| originator |
Servier |
| Quality Level |
100  |
| SMILES string |
O.[Na+].CN1c2ccccc2C(NCCCCCCC([O-])=O)c3ccc(Cl)cc3S1(=O)=O |
| solubility |
DMSO: ≥20 mg/mL |
| storage condition |
desiccated |
| storage temp. |
room temp |
| Application: |
Tianeptine sodium salt hydrate has been used as a selective serotonin reuptake enhancer (SSRE) positive control during serotonin transporter (SERT) assay in human embryonic kidney 293 cell lines. |
| Biochem/physiol Actions: |
Tianeptine is a tricyclic antidepressant that enhances serotonin uptake. This drug can affect neuroprotection, neuronal excitability, memory and anxiety. However, tianeptine is not linked to adverse psychomotor, cognitive, cardiovascular, sleep and bodyweight effects. The drug has a low tendency for abuse and has a positive pharmacokinetic profile. |
| Biochem/physiol Actions: |
Tianeptine is least involved in drug interaction as it is not metabolized by cytochrome P450 system in the liver. In hippocampus and amygdala, tianeptine is involved in glutamatergic transmission processes and elicits neuroplasticity. |
| Features and Benefits: |
This compound was developed by Servier . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here . |
| General description: |
Tianeptine is a μ-opioid receptor (MOR) as well as a δ-opioid receptor (DOR) agonist. |
| Packaging: |
5, 25 mg in glass bottle |
| Preparation Note: |
Tianeptine sodium salt hydrate is soluble in DMSO at a concentration that is greater than or equal to 20 mg/ml. |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥98% (HPLC) |
| Storage Temp. |
room temp |
| UNSPSC |
12352200 |
