Tobramycin sulfate salt

SIGMA/T1783 - aminoglycoside antibiotic

Synonym: Nebramycin Factor 6 sulfate

Empirical Formula (Hill Notation): C₁₈H₃₇N₅O₉ · xH₂SO₄
Molecular Weight: 467.51 (free base basis)
MDL Number: MFCD00133864
Linear Formula: C₁₈H₃₇N₅O₉ · xH₂SO₄
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-T1783-100MG	100 mg	$81.60 1/EA	Add To Favorites
45-T1783-500MG	500 mg	$283.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: T1783-100MG

Properties
Descriptions
Safety Info.
Basic Data

antibiotic activity spectrum	Gram-negative bacteria
biological source	Streptomyces tenebrarius
color	white to off-white
form	powder
InChI	1S/C18H37N5O9.H2O4S/c19-3-9-8(25)2-7(22)17(29-9)31-15-5(20)1-6(21)16(14(15)28)32-18-13(27)11(23)12(26)10(4-24)30-18;1-5(2,3)4/h5-18,24-28H,1-4,19-23H2;(H2,1,2,3,4)/t5-,6+,7+,8-,9+,10+,11-,12+,13+,14-,15+,16-,17+,18+;/m0./s1
InChI key	ZEUUPKVZFKBXPW-TWDWGCDDSA-N
mode of action	protein synthesis \| interferes
potency	634-739 μg per mg
Quality Level	200
SMILES string	OS(O)(=O)=O.NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](N)C[C@@H]1O
solubility	H₂O: soluble 50 mg/mL
storage condition	(Keep container tightly closed in a dry and well-ventilated place. Hygroscopic.)
storage temp.	2-8°C

Application:	Tobramycin is an aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius. It is effective against gram-negative bacteria, especially the pseudomonas species. It is not effective against Enterococci. It is used to inhibit bacterial protein synthesis at the level of 30S (16S rRNA) and 70S ribosomal complex assembly. It is used to treat pseudomonas aeruginosa lung infections and is used in combination with other antibiotics to treat urinary tract infections, gynecologic infections, peritonitis, endocarditis, pneumonia, sepsis, respiratory infections, osteomyelitis and other soft-tissue infections. It is a potential therapy for sinus infections. Product T1783 has been used to study antibiotic resistance.
Biochem/physiol Actions:	Tobramycin binds irreversibly to one of two aminoglycoside binding sites on the 30 S ribosomal subunit, inhibiting bacterial protein synthesis. Tobramycin may also destabilize bacterial membranes by binding to 16 S r-RNA. It inhibits translocation and elicits miscoding. Tobramycin binds to an RNA aptamer, which is structurally similar to the A site of 16S rRNA.
Biochem/physiol Actions:	Tobramycin sulfate is an aminoglycoside. Mode of Action: Binds to 70S ribosomal subunit; inhibits translocation; elicits miscoding. Spectrum of Activity: Gram negative bacteria. Not effective against Enterococci.
Caution:	Hygroscopic
General description:	Chemical structure: aminoglycoside
Other Notes:	Keep container tightly closed in a dry and well-ventilated place. Hygroscopic.
Packaging:	100, 500 mg in glass bottle
Packaging:	100MG,500MG

Symbol	GHS07,GHS08
Signal word	Danger
Hazard statements	H312 + H332 - H360
Precautionary statements	P201 - P202 - P280 - P302 + P352 + P312 - P304 + P340 + P312 - P308 + P313
Hazard Codes	T
Risk Statements	61-20/21/22
Safety Statements	53-22-36/37/39-45
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Storage Temp.	2-8°C
UNSPSC	51101500

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