Tobramycin sulfate salt
SIGMA/T1783 - aminoglycoside antibiotic
Synonym: Nebramycin Factor 6 sulfate
Empirical Formula (Hill Notation): C18H37N5O9 · xH2SO4
Molecular Weight: 467.51 (free base basis)
MDL Number: MFCD00133864
Linear Formula: C18H37N5O9 · xH2SO4
Product Type: Chemical
antibiotic activity spectrum | Gram-negative bacteria |
biological source | Streptomyces tenebrarius |
color | white to off-white |
form | powder |
InChI | 1S/C18H37N5O9.H2O4S/c19-3 |
InChI key | ZEUUPKVZFKBXPW-TWDWGCDDSA |
mode of action | protein synthesis | interferes |
potency | 634-739 μg per mg |
Quality Level | 200 ![]() |
SMILES string | OS(O)(=O)=O.NC[C@H]1O[C@H |
solubility | H2O: soluble 50 mg/mL |
storage condition | (Keep container tightly closed in a dry and well-ventilated place. Hygroscopic.) |
storage temp. | 2-8°C |
Application: | Tobramycin is an aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius. It is effective against gram-negative bacteria, especially the pseudomonas species. It is not effective against Enterococci. It is used to inhibit bacterial protein synthesis at the level of 30S (16S rRNA) and 70S ribosomal complex assembly. It is used to treat pseudomonas aeruginosa lung infections and is used in combination with other antibiotics to treat urinary tract infections, gynecologic infections, peritonitis, endocarditis, pneumonia, sepsis, respiratory infections, osteomyelitis and other soft-tissue infections. It is a potential therapy for sinus infections. Product T1783 has been used to study antibiotic resistance. |
Biochem/physiol Actions: | Tobramycin binds irreversibly to one of two aminoglycoside binding sites on the 30 S ribosomal subunit, inhibiting bacterial protein synthesis. Tobramycin may also destabilize bacterial membranes by binding to 16 S r-RNA. It inhibits translocation and elicits miscoding. Tobramycin binds to an RNA aptamer, which is structurally similar to the A site of 16S rRNA. |
Biochem/physiol Actions: | Tobramycin sulfate is an aminoglycoside. Mode of Action: Binds to 70S ribosomal subunit; inhibits translocation; elicits miscoding. Spectrum of Activity: Gram negative bacteria. Not effective against Enterococci. |
Caution: | Hygroscopic |
General description: | Chemical structure: aminoglycoside |
Other Notes: | Keep container tightly closed in a dry and well-ventilated place. Hygroscopic. |
Packaging: | 100, 500 mg in glass bottle |
Packaging: | 100MG,500MG |
Symbol | ![]() ![]() |
Signal word | Danger |
Hazard statements | H312 + H332 - H360 |
Precautionary statements | P201 - P202 - P280 - P302 + P352 + P312 - P304 + P340 + P312 - P308 + P313 |
Hazard Codes | T |
Risk Statements | 61-20/21/22 |
Safety Statements | 53-22-36/37/39-45 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Storage Temp. | 2-8°C |
UNSPSC | 51101500 |