Tyrphostin A9
SIGMA/T182 - solid
Synonym: Malonoben; [[3,5-
CAS Number: 10537-47-0
Empirical Formula (Hill Notation): C18H22N2O
Molecular Weight: 282.38
MDL Number: MFCD00209853
Linear Formula: C18H22N2O
Product Type: Chemical
assay | ≥98% (HPLC) |
biological source | synthetic (organic) |
color | yellow |
form | solid |
InChI | 1S/C18H22N2O/c1-17(2,3)14 |
InChI key | MZOPWQKISXCCTP-UHFFFAOYSA |
mp | 139-140 °C |
Quality Level | 100 ![]() |
SMILES string | CC(C)(C)c1cc(C=C(C#N)C# |
solubility | DMSO: <25 mg/mL |
ethanol: 20 mg/mL | |
H2O: insoluble |
Application: | Tyrphostin A9 can be used for inhibiting tyrosine kinase functions in C2C12 cells. It has also been used to disrupt membrane potential in mammalian cells. |
Biochem/physiol Actions: | Tyrphostin A9 is a PDGF receptor tyrosine kinase inhibitor that can induce apoptosis in cancer cells, inhibit the growth of vascular smooth cells and block calcium release-dependent phosphorylations. |
Features and Benefits: | This compound is a featured product for Kinase Phosphatase Biology research. Click here ![]() ![]() |
Packaging: | 25 mg in poly bottle |
Packaging: | 5 mg in glass bottle |
Preparation Note: | Tyrphostin A9 is soluble in ethanol at 20 mg/ml, in DMSO at a concentration less than 25 mg/ml. It is insoluble in water. |
Symbol | ![]() |
Signal word | Danger |
Hazard statements | H301 + H311 |
Precautionary statements | P280 - P301 + P310 + P330 - P302 + P352 + P312 |
Hazard Codes | T |
Risk Statements | 23/24/25 |
Safety Statements | 36/37/39-45 |
RIDADR | UN 2811 6.1 / PGIII |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
mp | 139-140 °C |
UNSPSC | 12352200 |