Paclitaxel
SIGMA/T1912 - from Taxus yannanensis, powder
CAS Number: 33069-62-4
Empirical Formula (Hill Notation): C47H51NO14
Molecular Weight: 853.91
MDL Number: MFCD00869953
Linear Formula: C47H51NO14
Product Type: Chemical
antibiotic activity spectrum | neoplastics |
biological source | Taxus yannanensis |
color | white |
form | powder |
InChI | 1S/C47H51NO14/c1-25-31(60 |
InChI key | RCINICONZNJXQF-MZXODVADSA |
mode of action | DNA synthesis | interferes |
mp | 213 °C (dec.) (lit.) |
originator | Bristol-Myers Squibb |
Quality Level | 200 |
SMILES string | [H][C@@]12C[C@H](O)[C@@]3 |
solubility | acetonitrile: soluble |
DMSO: 50 mg/mL (can be stored frozen for several months) | |
ethanol: soluble | |
methanol: soluble (undergoes transesterification) | |
storage temp. | 2-8°C |
Application: | Paclitaxel has been used to study PREP2-tubulin interactions using coimmunoprecipitation assays on NIH3T3 cell extracts. This drug has also been used to stabilize tubulin obtained from pig brain. |
Biochem/physiol Actions: | Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase. The microtubule damage induces apoptosis through a JNK-dependent pathway followed by a JNK-independent pathway, perhaps related to the activation of protein kinase A (PKA) or of Raf-1 kinase, resulting in phosphorylation of Bcl-2. A major metabolite via CYP2CB is 6α-hydroxypaclitaxel (6α-OHP). |
Caution: | Paclitaxel undergoes transesterification in methanol and hydrolyzes in aqueous solutions. |
Features and Benefits: | This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm . |
Features and Benefits: | This compound was developed by Bristol-Myers Squibb . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here . |
General description: | Chemical structure: taxoide |
Packaging: | 1, 5, 25 mg in glass bottle |
Preparation Note: | Paclitaxel is soluble in DMSO at 50 mg/ml and can be stored frozen for several months. It is also soluble in methanol (undergoes transesterification), acetonitrile and ethanol. Paclitaxel is rapidly destroyed in weakly alkaline, methanolic solutions and in strongly acidic methanolic solutions (1:1 of methanol:concentrated HCl). It is also soluble in a mixture of 50% Cremophor EL and 50% anhydrous ethanol. |
Symbol | GHS05,GHS07,GHS08 |
Signal word | Danger |
Hazard statements | H315 - H317 - H318 - H334 - H335 - H340 - H360D - H372 |
Precautionary statements | P202 - P260 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313 |
Hazard Codes | Xn |
Risk Statements | 37/38-41-42/43-62-68 |
Safety Statements | 22-26-36/37/39-45 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
mp | 213 °C (dec.) (lit.) |
Storage Temp. | 2-8°C |
UNSPSC | 12161501 |