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Trichostatin A, Ready Made Solution

SIGMA/T1952 - 5 mM in DMSO, from Streptomyces sp.

Synonym: TSA; [R-(E,E)]-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide

CAS Number: 58880-19-6
Empirical Formula (Hill Notation): C17H22N2O3
Molecular Weight: 302.37
Linear Formula: C17H22N2O3
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-T1952-200UL 200 µL
 $89.80
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antibiotic activity spectrum fungi
  neoplastics
assay ≥98% (HPLC)
biological source Streptomyces sp.
concentration 5 mM in DMSO
form DMSO solution
InChI 1S/C17H22N2O3/c1-12(5-10-16(20)18-22)11-13(2)17(21)14-6-8-15(9-7-14)19(3)4/h5-11,13,22H,1-4H3,(H,18,20)/b10-5+,12-11+
InChI key RTKIYFITIVXBLE-WKWSCTOISA-N
mode of action enzyme | inhibits
Quality Level 200 
shipped in dry ice
SMILES string N(O)C(=O)C=CC(=CC(C)C(=O)c1ccc(cc1)N(C)C)C
storage temp. −20°C
technique(s) cell culture | mammalian: suitable
Application: Trichostatin A, ready-made solution has been used:
• as a histone deacetylase inhibitor to study its effect on transcriptome changes by stem cell testing
• to inhibit histone deacetylase (HDAC) class I, II, or III in primary pituitary cell cultures and to investigate insulin control of endogenous human growth hormone gene (hGH)
• to treat cells for the HDAC inhibition experiments
Biochem/physiol Actions: Trichostatin A (TSA) is a Streptomyces metabolite, which specifically inhibits mammalian histone deacetylase at a nanomolar concentration and causes accumulation of highly acetylated histone molecules in mammalian cells. For that reason, trichostatin A is a tool to study the consequences of histone acetylation in vivo. Trichostatin A induces cell differentiation, cell cycle arrest, reversal of transformed cells morphology, and apoptosis and is able to modulate transcription. TSA has been used to establish a new cloning technique, which increases the success rates for mouse cloning.
Biochem/physiol Actions: Trichostatin A is a Streptomyces metabolite, which specifically inhibits mammalian histone deacetylase.
General description: Trichostatin A is a compound of primary hydroxamic acid.
RIDADR NA 1993 / PGIII
WGK Germany WGK 1
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352202

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