(1,2,5,6-Tetrahydropyridin-4-yl)methylphosphinic acid hydrate
SIGMA/T200 - ≥97% (HPLC), solid
Synonym: TPMPA hydrate
CAS Number: 182485-36-5 (anhydrous)
Empirical Formula (Hill Notation): C6H12NO2P · xH2O
Molecular Weight: 161.14 (anhydrous basis)
Linear Formula: C6H12NO2P · xH2O
Product Type: Chemical
assay | ≥97% (HPLC) |
color | white to off-white |
form | solid |
InChI | 1S/C6H12NO2P.H2O/c1-10(8, |
InChI key | GXVWAQPRAQORGS-UHFFFAOYSA |
Quality Level | 100 ![]() |
SMILES string | [H]O[H].CP([O-])(=O)C1=CC |
solubility | DMSO: insoluble |
H2O: 16 mg/mL |
Application: | (1,2,5,6-Tetrahydropyridi |
Application: | TPMA has been used as a GABAC receptor antagonist to study the role of inner retinal inhibition in midget ganglion cells. TPMPA has also been used to study the role of GABAC receptor antagonists in suppressing orientation selectivity in ganglion cells. |
Biochem/physiol Actions: | TPMPA is a hybrid of isoguvacine and 3-APMPA designed to retain affinity for GABAC receptors but not to interact with GABAA or GABAB receptors. Electrical assays show that TPMPA is a competitive antagonist of cloned human mu 1 GABAC receptors expressed in Xenopus laevis oocytes (Kb approx. 2 μM). TPMPA is >100-fold weaker as an inhibitor of rat brain GABAA receptors expressed in oocytes (Kb approx. 320 μM) and has only weak agonist activity on GABAB receptors assayed in rat hippocampal slices (EC50 approx. 500 μM). TPMPA may be used to investigate GABAC receptor function in the outer retina and in any other areas of the nervous system in which these types of receptor are present. |
Features and Benefits: | This compound is a featured product for Neuroscience research. Click here ![]() ![]() |
Features and Benefits: | This compound is featured on the GABAC Receptors ![]() ![]() |
Legal Information: | Sold in the USA under exclusive license from the University of California. |
Packaging: | 10, 50 mg in glass bottle |
Preparation Note: | (1,2,5,6-Tetrahydropyridi |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥97% (HPLC) |
UNSPSC | 12352200 |