Thebaine
SIGMA/T2019 - powder
Synonym: Paramorphine
CAS Number: 115-37-7
Empirical Formula (Hill Notation): C19H21NO3
Molecular Weight: 311.37
EC Number: 204-084-1
MDL Number: MFCD00027409
Linear Formula: C19H21NO3
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: T2019-1G
| drug control | USDEA Schedule II; Home Office Schedule 2; stupéfiant (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal) |
| form | powder |
| InChI | 1S/C19H21NO3/c1-20-9-8-19 |
| InChI key | FQXXSQDCDRQNQE-VMDGZTHMSA |
| Quality Level | 200  |
| SMILES string | [H][C@@]12Oc3c(OC)ccc4C[C |
| solubility | alcohol: soluble 1 in 10 of alcohol |
| benzene: soluble 1 in 18 in benzene | |
| chloroform: soluble 50 mg/ml, clear, yellow | |
| diethyl ether: soluble 1 in 135 of ether | |
| H2O: insoluble |
| Application: | Thebaine has been used for the synthesis of neopinone/codeinone ring systems. Thebaine has also been used as a 1 mg/ml standard in methanol for urine thebaine analysis in individuals who had consumed poppy seeds. |
| Biochem/physiol Actions: | The (-)-isomer of thebaine is the naturally-occurring constituent of opium that is a precursor of morphine. It has poor antinociceptive activity and induces convulsions. It binds to μ and δ opioid receptors in vitro. |
| Physical form: | Alkaloid powder |
| Preparation Note: | Thebaine dissolves in chloroform at 50 mg/ml to yield a clear, yellow solution. It soluble in alcohol, ether, and benzene at 1:10, 1: 135, and 1:18 parts respectively. However, thebaine does not dissolve in water. |
| Symbol |  GHS06 |
| Signal word | Danger |
| Hazard statements | H301 - H336 |
| Precautionary statements | P301 + P310 + P330 |
| Hazard Codes | T+ |
| Risk Statements | 26/27/28 |
| Safety Statements | 22-36/37/39-45 |
| RIDADR | UN 1544PSN1 6.1 / PGIII |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| UNSPSC | 12352200 |